About: Alzheimer's disease and oxidative stress. A review

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/24059239
Description	Alzheimer's disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development. Alzheimer's disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development. (en)
Title	Alzheimer's disease and oxidative stress. A review Alzheimer's disease and oxidative stress. A review (en)
skos:prefLabel	Alzheimer's disease and oxidative stress. A review Alzheimer's disease and oxidative stress. A review (en)
skos:notation	RIV/60162694:G44__/14:43875038!RIV15-MO0-G44_____
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	2297
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/14:43875038
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	reactive oxygen species; Parkinson's disease; mitochondria; heavy metals; Fenton reaction; antioxidants; tau; amyloid plaque; Alzheimer disease (en)
http://linked.open.../riv/klicoveSlovo	Fenton reaction Parkinson's disease antioxidants mitochondria Alzheimer disease heavy metals tau reactive oxygen species amyloid plaque
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[0C8F5AD9478F]
http://linked.open...i/riv/nazevZdroje	Current Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos	000331447400007
issn	0929-8673
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/09298673113206660258
http://localhost/t...ganizacniJednotka	G44

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