About: Melatonin Changes tularemia progression in a BALB/c mouse model

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327
Description	Melatonin is a hormone with antioxidant properties. In the body, melatonin is involved in regulation of circadian biological rhythm. However, receptors for melatonin are expressed on disparate organs and they can be found on immune cells as well. The present experiment is focused on research whether melatonin would regulate pathogenesis caused by a model intracellular pathogen, Francisella tularensis. For the reason, laboratory mice BALB/c were infected with F. tularensis. Melatonin was given in two doses: 10 and 100 µg/kg. Animals were sacrificed after either three or five days. Spleen and liver were sampled for bacterial burden. Interferon gamma (IFN-gama), interleukin 2 (IL-2) and total immunoglobulins were assayed from plasma samples. We proved that melatonin is able to reduce bacterial burden in the organs in a dose response manner. Surprisingly, IFN-gama and IL-2 levels were reduced as well. Immunoglobulins remained unchanged. We conclude our experiment that melatonin is potent to reduce tularemia progression. We infer that the effect of melatonin lay in regulation of cell cycle rather than immunity regulation. Melatonin is a hormone with antioxidant properties. In the body, melatonin is involved in regulation of circadian biological rhythm. However, receptors for melatonin are expressed on disparate organs and they can be found on immune cells as well. The present experiment is focused on research whether melatonin would regulate pathogenesis caused by a model intracellular pathogen, Francisella tularensis. For the reason, laboratory mice BALB/c were infected with F. tularensis. Melatonin was given in two doses: 10 and 100 µg/kg. Animals were sacrificed after either three or five days. Spleen and liver were sampled for bacterial burden. Interferon gamma (IFN-gama), interleukin 2 (IL-2) and total immunoglobulins were assayed from plasma samples. We proved that melatonin is able to reduce bacterial burden in the organs in a dose response manner. Surprisingly, IFN-gama and IL-2 levels were reduced as well. Immunoglobulins remained unchanged. We conclude our experiment that melatonin is potent to reduce tularemia progression. We infer that the effect of melatonin lay in regulation of cell cycle rather than immunity regulation. (en)
Title	Melatonin Changes tularemia progression in a BALB/c mouse model Melatonin Changes tularemia progression in a BALB/c mouse model (en)
skos:prefLabel	Melatonin Changes tularemia progression in a BALB/c mouse model Melatonin Changes tularemia progression in a BALB/c mouse model (en)
skos:notation	RIV/60162694:G44__/13:43874970!RIV14-MO0-G44_____
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	27
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Pohanka, Doc. RNDr. PhD, Miroslav Pavliš, Oto
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	87155
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/13:43874970
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidative stress; interleukin 2; interferon gamma; tularemia; Francisella tularensis; melatonin (en)
http://linked.open.../riv/klicoveSlovo	melatonin tularemia Francisella tularensis oxidative stress interleukin 2 interferon gamma
http://linked.open...odStatuVydavatele	NG - Nigerijská federativní republika
http://linked.open...ontrolniKodProRIV	[E1C548D52F02]
http://linked.open...i/riv/nazevZdroje	African Journal of Pharmacy and Pharmacology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Pohanka, Miroslav Pavliš, Oto
issn	1996-0816
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.5897/AJPP2013.3496
http://localhost/t...ganizacniJednotka	G44

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