About: Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX

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About: Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://benthamscience.com/journal/contents.php?journalID=mc&issueID=111593
Description	Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with these agents. None from the known AChE reactivators is able to reactivate AChE inhibited by all kinds of nerve agents. In this work, reactivation potency of seventeen structurally different AChE reactivators was tested in vitro and subsequently, relationship between their chemical structure and biological activity was outlined. VX was chosen as appropriate member of the nerve agent family. Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with these agents. None from the known AChE reactivators is able to reactivate AChE inhibited by all kinds of nerve agents. In this work, reactivation potency of seventeen structurally different AChE reactivators was tested in vitro and subsequently, relationship between their chemical structure and biological activity was outlined. VX was chosen as appropriate member of the nerve agent family. (en)
Title	Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX (en)
skos:prefLabel	Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX (en)
skos:notation	RIV/60162694:G44__/13:43874603!RIV14-MZ0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LH13009), P(NT12062)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Soukup, Ondřej Hrabinová, Martina Pejchal, Jaroslav Jun, Daniel Žďárová Karasová, Jana Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	108424
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/13:43874603
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxime; acetylcholinesterase; reactivation; VX; Nerve agent (en)
http://linked.open.../riv/klicoveSlovo	VX acetylcholinesterase reactivation oxime Nerve agent
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[81A257B7FFDA]
http://linked.open...i/riv/nazevZdroje	Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The research of modified cholinesterase reactivators for organophosphorus pesticide poisoning treatment Preparation and biological evaluation of new therapeutics against to pesticides
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuča, Kamil Musílek, Kamil Pejchal, Jaroslav Žďárová Karasová, Jana Jun, Daniel Soukup, Ondřej
http://linked.open...ain/vavai/riv/wos	000320326200007
issn	1573-4064
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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