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Description
| - We studied effect of valproic acid, a representative of histondeacetylases inhibitors, on cell cycle and protein expression in U-937 PML/RAR cells of human histiocytic lymphoma. Moreover, we tried to potentiate its effect by concomitant treatment with the differentiation agent all-trans retinoic acid. We proved acetylation of nuclear histones H3 and H4 after VA treatment. Activation of non-histone proteins (as p21) preceded this acetylation. Protein p21 as an inhibitor of cyclin dependent kinases causes cell cycle arrest in G1, resulting in a decrease of the percentage of cells in the S phase, as well as in the inhibition of the proliferation, which we demonstrated after VA treatment. Using concomitant treatment with VA and ATRA failed to yield a synergistic or additive effect on p21 expression in our experiments. Thus different treatment schedules should be the aim of further studies.
- We studied effect of valproic acid, a representative of histondeacetylases inhibitors, on cell cycle and protein expression in U-937 PML/RAR cells of human histiocytic lymphoma. Moreover, we tried to potentiate its effect by concomitant treatment with the differentiation agent all-trans retinoic acid. We proved acetylation of nuclear histones H3 and H4 after VA treatment. Activation of non-histone proteins (as p21) preceded this acetylation. Protein p21 as an inhibitor of cyclin dependent kinases causes cell cycle arrest in G1, resulting in a decrease of the percentage of cells in the S phase, as well as in the inhibition of the proliferation, which we demonstrated after VA treatment. Using concomitant treatment with VA and ATRA failed to yield a synergistic or additive effect on p21 expression in our experiments. Thus different treatment schedules should be the aim of further studies. (en)
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Title
| - Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells
- Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells (en)
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skos:prefLabel
| - Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells
- Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells (en)
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skos:notation
| - RIV/60162694:G44__/12:43874776!RIV13-MO0-G44_____
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/12:43874776
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - U-937 cells; protein p21; all-trans retinoic acid; valproic acid (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Plzeňský lékařský sborník
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Muthná, Darina
- Vávrová, Jiřina
- Řezáčová, Martina
- Janská, Božena
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number of pages
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http://localhost/t...ganizacniJednotka
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