About: Acute toxicity of surfactants and detergend-based decontaminants in mice and rats

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://mmsl.cz/viCMS/soubory/pdf/MMSL_2012_4_3_WWW.pdf
Description	Detergent-based mixtures and pure surfactants used as decontaminants in mass casualty scenarios were investigated for their acute 24 h toxicity. Commercial detergents NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM were tested in male Wistar rats after percutaneous, peroral and intramuscular administration. Pure surfactants althosan MB, sodium alkylbenzene sulphonate, triton X, benzyl dimethyl dodecyl ammonium chloride, and N-dodecyl pyridinium bromide were investigated in male ICR mice. Estimated LD50 of surfactants varied from < 100 mg.kg-1 (i.m.) to more than 2000 mg.kg-1 (p.o, p.c.) in mice. All detergents tested in rats were rather less toxic (LD50 > 6 ml.kg-1), thus could be considered as safe if used as external skin decontaminant or if low volume is accidentally ingested. Detergent-based mixtures and pure surfactants used as decontaminants in mass casualty scenarios were investigated for their acute 24 h toxicity. Commercial detergents NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM were tested in male Wistar rats after percutaneous, peroral and intramuscular administration. Pure surfactants althosan MB, sodium alkylbenzene sulphonate, triton X, benzyl dimethyl dodecyl ammonium chloride, and N-dodecyl pyridinium bromide were investigated in male ICR mice. Estimated LD50 of surfactants varied from < 100 mg.kg-1 (i.m.) to more than 2000 mg.kg-1 (p.o, p.c.) in mice. All detergents tested in rats were rather less toxic (LD50 > 6 ml.kg-1), thus could be considered as safe if used as external skin decontaminant or if low volume is accidentally ingested. (en)
Title	Acute toxicity of surfactants and detergend-based decontaminants in mice and rats Acute toxicity of surfactants and detergend-based decontaminants in mice and rats (en)
skos:prefLabel	Acute toxicity of surfactants and detergend-based decontaminants in mice and rats Acute toxicity of surfactants and detergend-based decontaminants in mice and rats (en)
skos:notation	RIV/60162694:G44__/12:43874672!RIV13-MO0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200803)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Misík, Jan Cabal, Jiří Kuča, Kamil Pavlíková, Růžena Vodáková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	121002
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/12:43874672
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute toxicity; surfactant; mass decontamination; tenside; detergent (en)
http://linked.open.../riv/klicoveSlovo	mass decontamination tenside detergent acute toxicity surfactant
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CD67A79F2995]
http://linked.open...i/riv/nazevZdroje	Military Medical Science Letters
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel decontaminants and disinfectants of skin based on micellar compounds
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	81
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Kuča, Kamil Misík, Jan Novotný, Ladislav Pavlíková, Růžena Vodáková, Eva
issn	0372-7025
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Acute toxicity of surfactants and detergend-based decontaminants in mice and rats

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