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Description
  • Tularemia, an infection caused by the intracellular gram-negative bacterium Francisella tularensis, is accompanied by high mortality and occurs throughout the Northern Hemisphere. The causative agent is also considered one of the most important biological warfare agents. As well as its taxonomy and epidemiology, the basic immunochemical, biochemical, and molecular approaches for disease diagnosis are outlined in this review. Aspects of immune responses during tularemia and damage to specific organs are discussed with regards to the predictive value of standard biomarkers. Bacterial burden is also considered as a limitation for polymerase-chain-reaction-based diagnosis.
  • Tularemia, an infection caused by the intracellular gram-negative bacterium Francisella tularensis, is accompanied by high mortality and occurs throughout the Northern Hemisphere. The causative agent is also considered one of the most important biological warfare agents. As well as its taxonomy and epidemiology, the basic immunochemical, biochemical, and molecular approaches for disease diagnosis are outlined in this review. Aspects of immune responses during tularemia and damage to specific organs are discussed with regards to the predictive value of standard biomarkers. Bacterial burden is also considered as a limitation for polymerase-chain-reaction-based diagnosis. (en)
Title
  • Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review
  • Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review (en)
skos:prefLabel
  • Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review
  • Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review (en)
skos:notation
  • RIV/60162694:G44__/11:00002449!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LH11023), S, V
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 194196
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/11:00002449
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Francisella tularensis; tularaemia; zoonosis; pathogenesis; assay (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [840C9A69193A]
http://linked.open...i/riv/nazevZdroje
  • Veterinární medicína
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 59
http://linked.open...iv/tvurceVysledku
  • Banďouchová, Hana
  • Chlíbek, Roman
  • Kuča, Kamil
  • Pikula, Jiří
  • Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos
  • 000296097000003
issn
  • 0375-8427
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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