About: Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.jcv.2010.09.014
Description	Varicella zoster virus typically causes benign disease in childhood - chickenpox - and can reactivate in adults as herpes zoster (HZ). However in immunocompromised patients, the infection with VZV can lead to severe complications leading to a fatal outcome. Here we describe a patient, who acquired primary VZV infection during 3 weeks lasting corticosteroid treatment. The disease took a fulminant course leading to a liver failure and severe coagulopathy resulting in death after 9 days post admission to the hospital, despite an intensive antiviral and supportive treatment. Wild-type VZV DNA was detected from multiple samples from esophagus, liver and skin. Genotypic analysis based on characterization of single nucleotide polymorphisms in open reading frames (ORFs) 54, 38 and 62 together with genotyping of ORFs 22, 21 and 50 characterized this VZV isolate as M2 strain, which is typically found in tropical countries. This is the first description of such strain from a patient in Czech Republic. Varicella zoster virus typically causes benign disease in childhood - chickenpox - and can reactivate in adults as herpes zoster (HZ). However in immunocompromised patients, the infection with VZV can lead to severe complications leading to a fatal outcome. Here we describe a patient, who acquired primary VZV infection during 3 weeks lasting corticosteroid treatment. The disease took a fulminant course leading to a liver failure and severe coagulopathy resulting in death after 9 days post admission to the hospital, despite an intensive antiviral and supportive treatment. Wild-type VZV DNA was detected from multiple samples from esophagus, liver and skin. Genotypic analysis based on characterization of single nucleotide polymorphisms in open reading frames (ORFs) 54, 38 and 62 together with genotyping of ORFs 22, 21 and 50 characterized this VZV isolate as M2 strain, which is typically found in tropical countries. This is the first description of such strain from a patient in Czech Republic. (en)
Title	Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain (en)
skos:prefLabel	Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain (en)
skos:notation	RIV/60162694:G44__/11:00002424!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1161), Z(MO0FVZ0000502), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Chlíbek, Roman Boštík, Pavel Boštíková, Vanda
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	200504
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002424
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	varicella - zoster virus; hepatitis; immunosuppression; mosaic strain; single nucleotide polymorphisms; molecular epidemiology; wild - type virus (en)
http://linked.open.../riv/klicoveSlovo	hepatitis molecular epidemiology mosaic strain single nucleotide polymorphisms varicella wild immunosuppression
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[153C24C7AF62]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Virology
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of virus-associated host-derived proteins in virus induced T cell dysfunction
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Boštík, Pavel Boštíková, Vanda Chlíbek, Roman Kosina, P. Laco, J. Plíšek, S. Plíšková, L. Prášil, P. Vyroubal, P.
http://linked.open...ain/vavai/riv/wos	000286094300016
http://linked.open...n/vavai/riv/zamer	Implementation of the new information of hygiene, preventive medicine and epidemiology into the military health care Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	1386-6532
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 68 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software