About: Pralidoxime - the gold standard of acetylcholinesterase reactivators

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this work we aim to summarize the universality of this compound, its reactivatiom potency when different cholinesterase inhibitors are used. Background: Pralidoxime is considered as a gold standard of acetylcholinesterase reactivators - antidotes used in case of nerve agent poisonings. It is commercially available worldwide since many years back. However, several studies describe this oxime as an old-fashion antidote Methods: Pralidoxime was synthesized at our department. The reactivating efficacy was tested on 10% (w/v) rat brain homogenate that was incubated with appropriate inhibitor for 30 minutes to reach 96% inhibition of AChE. Then, pralidoxime was added for 10 minutes. Measurements were performed at 25 °C, pH 8, and at the concentrations of the AChE reactivators at 10-3 and 10-5 M. The activities of brain AChE were measured by a potentiostatic method. Results: No sufficient reactivation was achieved at the concentration 10-5 M, which is a concentration that is possible to reach after adm In this work we aim to summarize the universality of this compound, its reactivatiom potency when different cholinesterase inhibitors are used. Background: Pralidoxime is considered as a gold standard of acetylcholinesterase reactivators - antidotes used in case of nerve agent poisonings. It is commercially available worldwide since many years back. However, several studies describe this oxime as an old-fashion antidote Methods: Pralidoxime was synthesized at our department. The reactivating efficacy was tested on 10% (w/v) rat brain homogenate that was incubated with appropriate inhibitor for 30 minutes to reach 96% inhibition of AChE. Then, pralidoxime was added for 10 minutes. Measurements were performed at 25 °C, pH 8, and at the concentrations of the AChE reactivators at 10-3 and 10-5 M. The activities of brain AChE were measured by a potentiostatic method. Results: No sufficient reactivation was achieved at the concentration 10-5 M, which is a concentration that is possible to reach after adm (en)
Title	Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro (en)
skos:prefLabel	Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro (en)
skos:notation	RIV/60162694:G44__/10:00002398!RIV11-MSM-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME 865)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Soukup, Ondřej Hrabinová, Martina Žďárová Karasová, Jana Kuča, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	280843
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002398
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cholinesterase; reactivator; oxime; inhibitor; pralidoxime (en)
http://linked.open.../riv/klicoveSlovo	pralidoxime cholinesterase inhibitor oxime reactivator
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[289AEB55EA02]
http://linked.open...i/riv/nazevZdroje	Bratislava Medical Journal-Bratislavske Lekarske Listy
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20865
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	111
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuča, Kamil Pohanka, Miroslav Žďárová Karasová, Jana Soukup, Ondřej Tobin, G.
http://linked.open...ain/vavai/riv/wos	000283482300007
issn	0006-9248
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro

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