About: Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase

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About: Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oxime K027 is a low-toxic bisquaternary compound originally developed as a reactivator of acetylcholinesterase (AChE) inhibited by nerve agents. The reactivation potency of K027 has been tested as a potential reactivator of AChE inhibited by tabun, sarin, cyclosarin, soman, VX, Russian VX, paraoxon, methylchlorpyrifos, and DDVP. The results show that oxime K027 reactivated AChE inhibited by almost all tested inhibitors to more than 10%, which is believed to be enough for saving the lives of intoxicated organisms. In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. Oxime K027 is a low-toxic bisquaternary compound originally developed as a reactivator of acetylcholinesterase (AChE) inhibited by nerve agents. The reactivation potency of K027 has been tested as a potential reactivator of AChE inhibited by tabun, sarin, cyclosarin, soman, VX, Russian VX, paraoxon, methylchlorpyrifos, and DDVP. The results show that oxime K027 reactivated AChE inhibited by almost all tested inhibitors to more than 10%, which is believed to be enough for saving the lives of intoxicated organisms. In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. (en)
Title	Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase (en)
skos:prefLabel	Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase (en)
skos:notation	RIV/60162694:G44__/10:00002395!RIV11-MSM-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME 865)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hrabinová, Martina Jun, Daniel Kuča, Kamil Musílek, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	277885
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002395
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	K027; acetylcholinesterase; nerve agent; pesticide; reactivator; oxime; antidote; universal (en)
http://linked.open.../riv/klicoveSlovo	universal pesticide K027 acetylcholinesterase nerve agent oxime reactivator antidote
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[39D834244F3A]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20865
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuča, Kamil Musílek, Kamil Pohanka, Miroslav Jun, Daniel Ghosh, KK
http://linked.open...ain/vavai/riv/wos	000280636800009
issn	1475-6366
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Oxime K027 - novel low-toxic candidate for the universal reactivator of nerve agent and pesticide inhibited acetylcholinesterase

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