About: New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Twelve bisquaternary isoquinolinium derivatives differing in the linker between two heteroarenium rings were synthesized and tested for their potency to inhibit brain cholinesterases. Anticholinesterase activity grew up with lenght of the connecting chain. Possible binding to the enzyme cavity was described using software Autodock. LogP and molecular volume of prepared compounds were predicted. The highest probability of synthesized compounds to penetrate blood-brain barrier could be expected for the compound with the linker having eight methylenes. Twelve bisquaternary isoquinolinium derivatives differing in the linker between two heteroarenium rings were synthesized and tested for their potency to inhibit brain cholinesterases. Anticholinesterase activity grew up with lenght of the connecting chain. Possible binding to the enzyme cavity was described using software Autodock. LogP and molecular volume of prepared compounds were predicted. The highest probability of synthesized compounds to penetrate blood-brain barrier could be expected for the compound with the linker having eight methylenes. (en)
Title	New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity (en)
skos:prefLabel	New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity (en)
skos:notation	RIV/60162694:G44__/10:00002371!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MO0FVZ0000604), Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hrabinová, Martina Jun, Daniel Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	274633
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002371
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	quinolinium; quaternary compounds; inhibitor; cholinesterase; Alzheimer's disease; anticholinergic (en)
http://linked.open.../riv/klicoveSlovo	cholinesterase Alzheimer's disease inhibitor anticholinergic quaternary compounds quinolinium
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[F8AF9FC8D9B5]
http://linked.open...i/riv/nazevZdroje	Letters in Drug Design & Discovery
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuča, Kamil Paar, Martin Pohanka, Miroslav Jun, Daniel Opletalová, Veronika Binder, Jiří
http://linked.open...ain/vavai/riv/wos	000272791000001
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví Research of new drug structures
issn	1570-1808
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	New bisquaternary isoquinolinium inhibitors of brain cholinesterases - synthesis and anticholinesterase activity

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software