About: Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH2O(CH2)(2)OCH2 and CH2O(CH2)(4)OCH2 were tested for their potency to reactivate VX-inhibited AChE. Their reactivation potency was compared with currently available oximes such as pralidoxime, obidoxime and HI-6. Appropriate constants (affinity towards the intact and inhibited enzyme, reactivation rate) characterizing the reactivation process were determined. According to the data obtained, a new oxime with CH2O(CH2)(2)OCH2 linker reached as high reactivation potency as HI-6. The percentage of reactivation of the oxime with CH2O(CH2)(2)OCH2 linker was comparable to that of obidoxime at a concentration 10 M. Hence, these oximes may be worthy of future development for the treatment of nerve agent intoxications, especially, with lipophilic agents such as soman and cyclosarin. Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH2O(CH2)(2)OCH2 and CH2O(CH2)(4)OCH2 were tested for their potency to reactivate VX-inhibited AChE. Their reactivation potency was compared with currently available oximes such as pralidoxime, obidoxime and HI-6. Appropriate constants (affinity towards the intact and inhibited enzyme, reactivation rate) characterizing the reactivation process were determined. According to the data obtained, a new oxime with CH2O(CH2)(2)OCH2 linker reached as high reactivation potency as HI-6. The percentage of reactivation of the oxime with CH2O(CH2)(2)OCH2 linker was comparable to that of obidoxime at a concentration 10 M. Hence, these oximes may be worthy of future development for the treatment of nerve agent intoxications, especially, with lipophilic agents such as soman and cyclosarin. (en)
Title	Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker (en)
skos:prefLabel	Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker (en)
skos:notation	RIV/60162694:G44__/10:00002353!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200801)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Soukup, Ondřej Cabal, Jiří Pejchal, Jaroslav Jun, Daniel Kuča, Kamil Musílek, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	283989
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002353
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cholinesterase; nerve agent; VX; reactivator; oxime; HI-6 (en)
http://linked.open.../riv/klicoveSlovo	cholinesterase HI-6 VX nerve agent oxime reactivator
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3E732019DA36]
http://linked.open...i/riv/nazevZdroje	Environmental Toxicology and Pharmacology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Robotized system for in vitro evaluation of novel rectivators of acetylcholinesterase inhibited by nerve agents
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Kuča, Kamil Musílek, Kamil Pejchal, Jaroslav Pohanka, Miroslav Jun, Daniel Soukup, Ondřej Jung, YS Oh, K. A. Yang, GY
http://linked.open...ain/vavai/riv/wos	000279089000014
issn	1382-6689
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker

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