About: Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA

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About: Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article. Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article. (en)
Title	Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA (en)
skos:prefLabel	Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA (en)
skos:notation	RIV/60162694:G44__/10:00002297!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200805), S, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kuča, Kamil Musílek, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	291484
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002297
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; butyrylcholinesterase; Alzheimer`s disease; tacrine; inhibition selectivity (en)
http://linked.open.../riv/klicoveSlovo	tacrine Alzheimer`s disease inhibition selectivity acetylcholinesterase butyrylcholinesterase
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[165C52A24E2F]
http://linked.open...i/riv/nazevZdroje	Letters in Organic Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Dohnal, Vlastimil Kuča, Kamil Musílek, Kamil Pohanka, Miroslav Korábečný, Jan Opletalová, Veronika Holas, Ondřej
http://linked.open...ain/vavai/riv/wos	000277156500011
http://linked.open...n/vavai/riv/zamer	Research of new drug structures
issn	1570-1786
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA

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