About: Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts

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About: Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Enveloped viruses including the simian immunodeficiency virus (SIV) acquire host proteins upon egress from the host cells. Some studies have documented the potential positive and negative biological functions of such host proteins. We utilized proteomic analysis to identify differences in host proteins acquired by a single source of SIV replicating within CD4+ T cells from disease resistant sooty mangabeys (SM) and disease susceptible rhesus macaques (RM). Our results show 4 host-derived proteins that uniquely associated with SIV from RM but not SM, including 26 S protease subunit 7 (MSS1) that was shown to enhance HIV-1 'tat' mediated transactivation. Similarly, 28 host-derived proteins uniquely associated with SIV from SM, but not RM, which included several molecules associated with immune function such as CD2, TLR4, TLR9 and a bioactive form of IL-13. These proteins may have a potential role in contributing to the polarized clinical outcome in these 2 species of nonhuman primates. Enveloped viruses including the simian immunodeficiency virus (SIV) acquire host proteins upon egress from the host cells. Some studies have documented the potential positive and negative biological functions of such host proteins. We utilized proteomic analysis to identify differences in host proteins acquired by a single source of SIV replicating within CD4+ T cells from disease resistant sooty mangabeys (SM) and disease susceptible rhesus macaques (RM). Our results show 4 host-derived proteins that uniquely associated with SIV from RM but not SM, including 26 S protease subunit 7 (MSS1) that was shown to enhance HIV-1 'tat' mediated transactivation. Similarly, 28 host-derived proteins uniquely associated with SIV from SM, but not RM, which included several molecules associated with immune function such as CD2, TLR4, TLR9 and a bioactive form of IL-13. These proteins may have a potential role in contributing to the polarized clinical outcome in these 2 species of nonhuman primates. (en)
Title	Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts (en)
skos:prefLabel	Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts (en)
skos:notation	RIV/60162694:G44__/10:00002243!RIV11-GA0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1161)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Řehulka, Pavel Boštík, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	254689
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002243
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	simian immunodeficiency virus; CD4+ T cells (en)
http://linked.open.../riv/klicoveSlovo	simian immunodeficiency virus CD4+ T cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D43D670B6C81]
http://linked.open...i/riv/nazevZdroje	Retrovirology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of virus-associated host-derived proteins in virus induced T cell dysfunction
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Boštík, Pavel Řehulka, Pavel Ansari, A. A. Bhimani, S. Mayne, A. E. Rajan, D. Song, B. Stephenson, ST.
issn	1742-4690
number of pages	1 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts

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