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| rdf:type
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| Description
| - Běžná léčba otrav organofosfáty spočívá v podání anticholinergik a reaktivátorů (oximů). Oximy mohou reagovat, mimo vlastních cholinesteráz, přímo s cholinergními receptory. HI-6 je oxim který může toto působení vykazovat také. V této práci byl zkoumán vliv reaktivátoru HI-6 an acetylcholinesterázu (AChE) a butyrylcholinesterázu (BChE) a in vitro na muskarinové receptory. Studie byla realizována za použití biosenzoru, respektive testování tkání. Byly stanoveny hodnoty IC50 pro BChE a AChE. Ve studii byl vysloven předpoklad inhibice AChE při nižších koncentracích reaktivátoru a inhibici muskarinových receptorů při vyšších koncentracích. (cs)
- OBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and cholinesterase reactivators (oximes). Oximes can react - except their reactivating effect on cholinesterases - directly with cholinoreceptors. HI-6 is an oxime that may have an inhibitory effect on the muscarinic receptors, too. METHODS: In our work, we have investigated an influence of HI-6 on the acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and on the muscarinic receptors in vitro. The study was conducted using biosensor technique and on the rat bladder using in vitro test (tissue bath; methacholine as muscarinic agonist). IC50 for BChE from human serum was determined to be 1.01x10-6 M and for human erythrocytes AChE 3.31x10-6 M, respectively. CONCLUSION: We assume that the demonstrated contractile response can be attributed to the inhibition of the AChE at the lower concentration and to a predominant inhibition of muscarinic receptor at higher concentration
- OBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and cholinesterase reactivators (oximes). Oximes can react - except their reactivating effect on cholinesterases - directly with cholinoreceptors. HI-6 is an oxime that may have an inhibitory effect on the muscarinic receptors, too. METHODS: In our work, we have investigated an influence of HI-6 on the acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and on the muscarinic receptors in vitro. The study was conducted using biosensor technique and on the rat bladder using in vitro test (tissue bath; methacholine as muscarinic agonist). IC50 for BChE from human serum was determined to be 1.01x10-6 M and for human erythrocytes AChE 3.31x10-6 M, respectively. CONCLUSION: We assume that the demonstrated contractile response can be attributed to the inhibition of the AChE at the lower concentration and to a predominant inhibition of muscarinic receptor at higher concentration (en)
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| Title
| - The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
- Působení látky HI-6 na cholinesterázy a krysí močový měchýř (cs)
- The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder (en)
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| skos:prefLabel
| - The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
- Působení látky HI-6 na cholinesterázy a krysí močový měchýř (cs)
- The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder (en)
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| skos:notation
| - RIV/60162694:G44__/08:00001994!RIV09-MO0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00001994
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - HI-6; reactivator; cholinesterase; acetylcholinesterase; inhibition (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Neuroendocrinology Letters
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kassa, Jiří
- Kuča, Kamil
- Marek, Jan
- Musílek, Kamil
- Pohanka, Miroslav
- Fusek, Josef
- Jun, Daniel
- Soukup, Ondřej
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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