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| rdf:type
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| Description
| - Bylo zkoumáno využití a efektivita lidských antidot proti NPL u mikrokorýše Daphnia magna (Crustacea, Cladocera) intoxikovaných NPL tabunem. Bylo zjištěno, že antidota mohou být intoxikovaným dafniím s úspěchem podána. Byly testovány tři různé způsoby postupu: kombinace atropinu a reaktivátoru acetylcholinesterázy (trimedoxim), pouze atropin a pouze trimedoxim. Nejvhodnější se ukázala kombinace atropinu s trimedoximem s následnou terapií atropinem. Poměr uzdravených zvířat se s časem zvyšoval nejen v léčených skupinách, ale také v kontrolních. To lze vysvětlit spontánní reaktivací tabunem inhibované cholinesterázy dafnií, což by poukazovalo na rozdílný charakter mezi cholinesterázami savců a korýšů. (cs)
- Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated bya nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. Three different treatment regimens were tested: the combination of atropine and acetylcholinesterase reactivator (trimedoximewas chosen), atropine only and trimedoxime alone, too. The most efficientwas the combination of atropine and trimedoxime followed by treatment with atropine only. The proportion of recovered animals increased with time not only in treated groups but also in the control as well. This can be explained by a spontaneous reactivation of tabun-inhibited cholinesterase in daphnids probably indicating a difference between mammalian and crustacean cholinesterases.
- Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated bya nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. Three different treatment regimens were tested: the combination of atropine and acetylcholinesterase reactivator (trimedoximewas chosen), atropine only and trimedoxime alone, too. The most efficientwas the combination of atropine and trimedoxime followed by treatment with atropine only. The proportion of recovered animals increased with time not only in treated groups but also in the control as well. This can be explained by a spontaneous reactivation of tabun-inhibited cholinesterase in daphnids probably indicating a difference between mammalian and crustacean cholinesterases. (en)
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| Title
| - Daphnia intoxicated by nerve agent tabun can be treated using human antidotes
- Dafnie intoxikované nervově paralytickou látkou tabunem mohou být léčeny lidskými antidoty (cs)
- Daphnia intoxicated by nerve agent tabun can be treated using human antidotes (en)
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| skos:prefLabel
| - Daphnia intoxicated by nerve agent tabun can be treated using human antidotes
- Dafnie intoxikované nervově paralytickou látkou tabunem mohou být léčeny lidskými antidoty (cs)
- Daphnia intoxicated by nerve agent tabun can be treated using human antidotes (en)
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| skos:notation
| - RIV/60162694:G44__/08:00001987!RIV09-MO0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00001987
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Acetylcholinesterase; Atropine; Crustacea; Oxime; Organophosphates; Reactivator (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Environmental Toxicology and Pharmacology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kuča, Kamil
- Jun, Daniel
- Vesela, S.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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