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| Description
| - Pyridinium aldoximes are used as antidotes to organophosphorus cholinesterase inhibitors. All pyridinium aldoximes (oximes) are highly polar quaternary ammonium compounds showing low to minimal blood-brain-barrier (BBB) penetration. Oximes are separated using reversed-phase (RP) HPLC methods and/or thin-layer chromatography (TLC). The chemical structures, elementary compositions, molecular sizes and the calculated logP values of several mono- and bis-pyridinium aldoximes are given. Chromatographic and electrophoretic analyses of oximes are detailed, including the stationary and mobile phase composition and the mode of detection. Degradation pathways and products are also discussed. To characterize oximes lipophilicity/hydrophilicity an in silico method was used and expanded as to describe organophosphorus compound adducts with several pyridinium aldoximes.
- Pyridinium aldoximes are used as antidotes to organophosphorus cholinesterase inhibitors. All pyridinium aldoximes (oximes) are highly polar quaternary ammonium compounds showing low to minimal blood-brain-barrier (BBB) penetration. Oximes are separated using reversed-phase (RP) HPLC methods and/or thin-layer chromatography (TLC). The chemical structures, elementary compositions, molecular sizes and the calculated logP values of several mono- and bis-pyridinium aldoximes are given. Chromatographic and electrophoretic analyses of oximes are detailed, including the stationary and mobile phase composition and the mode of detection. Degradation pathways and products are also discussed. To characterize oximes lipophilicity/hydrophilicity an in silico method was used and expanded as to describe organophosphorus compound adducts with several pyridinium aldoximes. (en)
- Pyridinium aldoximy jsou užívány jako antidota organofosforových inhibitorů cholinesteráz. Všechny pyridiniové aldoximy (oximy) jsou vysoce polární kvartérní amoniové sloučeniny prokazující nízkou minimální blood-brain-barrier (BBB) průchodnost. Oximy jsou separovány užitím HPLC na reverzní fázi (RP) a/či tenkovrstevnou chromatografií (TLC). Chemická struktura, prvkové složení, molekulová velikost a kalkulované hodnoty logP některých mono- a bis-pyridiniových aldoximů jsou dány. Chromatografické a elektroforetické analýzy oximů jsou diskutovány, včetně složení stacionárních a mobilních fází a módů detekce. Degradační cesty a produkty jsou rovněž iskutovány. Za účelem charakterizace lipofility/hydrofility byla užita in silico metoda a rozšířena na popis aductů organofosforových součenin s některými pyridiniovými sloučeninami. (cs)
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| Title
| - Analysis of pyridinium aldoximes - a chromatographic approach
- Analýza pyridiniových aldoximů - chromatografický přístup. (cs)
- Analysis of pyridinium aldoximes - a chromatographic approach (en)
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| skos:prefLabel
| - Analysis of pyridinium aldoximes - a chromatographic approach
- Analýza pyridiniových aldoximů - chromatografický přístup. (cs)
- Analysis of pyridinium aldoximes - a chromatographic approach (en)
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| skos:notation
| - RIV/60162694:G44__/08:00001929!RIV09-GA0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00001929
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Pyridinium aldoximes; lipophilicity; chromatography; blood-brain-barrier penetration HPLC; blood (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - AE - Stát Spojené arabské emiráty
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Current Medicinal Chemistry
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kuča, Kamil
- Kalasz, H.
- Tekes, K.
- Csermely, T.
- Darvas, F.
- Ludanyi, K.
- Mudhafar, A. A.
- Petroianu, G.
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| http://linked.open...ain/vavai/riv/wos
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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