About: Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity

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About: Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Parathion, chlorpyrifos, and malathion are organophosphorus substances used as pesticides in agriculture. Due to the volume of their worldwide use, they are commonly encountered substances. These compounds inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of intoxication with these agents. Chlorpyrifos, a representative member of this pesticide family, was used to inhibit the AChE activity of rat brain. In this work, the reactivation activity of twenty-one structurally different AChE reactivators was tested in vitro and subsequently, the relationship between their chemical structure and biological activity was outlined. Parathion, chlorpyrifos, and malathion are organophosphorus substances used as pesticides in agriculture. Due to the volume of their worldwide use, they are commonly encountered substances. These compounds inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of intoxication with these agents. Chlorpyrifos, a representative member of this pesticide family, was used to inhibit the AChE activity of rat brain. In this work, the reactivation activity of twenty-one structurally different AChE reactivators was tested in vitro and subsequently, the relationship between their chemical structure and biological activity was outlined. (en)
Title	Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity (en)
skos:prefLabel	Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity (en)
skos:notation	RIV/60162694:G44__/07:00001813!RIV10-MSM-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME 865)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	447192
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001813
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; reactivators; structure-activity relationship; pesticide; organophosphates (en)
http://linked.open.../riv/klicoveSlovo	organophosphates pesticide structure-activity relationship acetylcholinesterase reactivators
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[6CEA1711B003]
http://linked.open...i/riv/nazevZdroje	Chemical Papers-Chemicke Zvesti
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20865
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Jun, Daniel Racakova, V.
issn	0366-6352
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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