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| rdf:type
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| Description
| - Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the design of new
- Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the design of new (en)
- Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace. (cs)
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| Title
| - Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace (cs)
- Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications
- Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications (en)
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| skos:prefLabel
| - Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace (cs)
- Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications
- Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications (en)
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| skos:notation
| - RIV/60162694:G44__/07:00001809!RIV09-GA0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/07:00001809
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Acetylcholinesterase; nerve agent; antidotes; cyclosarin; reactivators; oxime (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - AE - Stát Spojené arabské emiráty
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Current Pharmaceutical Design
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Bajgar, Jiří
- Kuča, Kamil
- Jun, Daniel
|
| issn
| |
| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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