About: In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon

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About: In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oximes are cholinesterase reactivators of use in poisoning with organophosphorus ester enzyme inhibitors. Pralidoxime (PRX) is the oxime used in the United States. Clinical experience with pralidoxime (and other oximes) is disappointing and the routine use has been questioned. Furthermore oximes are not equally effective against all existent enzyme inhibitors. There is a clear demand for 'broad spectrum' cholinesterase reactivators with a higher efficacy than those clinically available. To meet this need over the years new reactivators of cholinesterase of potential clinical utility have been developed. The purpose of the study was to quantify 'in vitro' the extent of protection conferred by available (pralidoxime and methoxime) and experimental (K-27, K-33 and K-48) oximes, using methyl-paraoxon (methyl-POX) as an esterase inhibitor and to compare the results with those previously obtained using paraoxon (POX) as an inhibitor. Red blood cell (RBC) acetylcholinesterase (AChE) act Oximes are cholinesterase reactivators of use in poisoning with organophosphorus ester enzyme inhibitors. Pralidoxime (PRX) is the oxime used in the United States. Clinical experience with pralidoxime (and other oximes) is disappointing and the routine use has been questioned. Furthermore oximes are not equally effective against all existent enzyme inhibitors. There is a clear demand for 'broad spectrum' cholinesterase reactivators with a higher efficacy than those clinically available. To meet this need over the years new reactivators of cholinesterase of potential clinical utility have been developed. The purpose of the study was to quantify 'in vitro' the extent of protection conferred by available (pralidoxime and methoxime) and experimental (K-27, K-33 and K-48) oximes, using methyl-paraoxon (methyl-POX) as an esterase inhibitor and to compare the results with those previously obtained using paraoxon (POX) as an inhibitor. Red blood cell (RBC) acetylcholinesterase (AChE) act (en) Byly testovány reaktivátory K027, K048 a K033 jakožto antidota při otravách methyl-paraoxonem in vitro. (cs)
Title	In vitro oximová reaktivace AChE čerbených krvinek inhibované methyl-paraoxonem (cs) In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon (en)
skos:prefLabel	In vitro oximová reaktivace AChE čerbených krvinek inhibované methyl-paraoxonem (cs) In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon (en)
skos:notation	RIV/60162694:G44__/07:00001806!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	168-175
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kassa, Jiří Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	425862
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001806
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cholinesterase; organophosphate; methyl-paraoxon; oxime; pralidoxime; methoxime; K-oxime (en)
http://linked.open.../riv/klicoveSlovo	pralidoxime organophosphate cholinesterase methoxime methyl-paraoxon oxime K-oxime
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E5E4F8427560]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Toxicology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Kuča, Kamil Nurulain, S. M. Petroianu, G. A. Arafat, K.
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	0260-437X
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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