About: Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase

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About: Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nine potential non-symmetrical xylene-bridged AChE reactivators were synthesized using modifications of currently known synthetic pathways. Their potency to reactivate AChE inhibited by the nerve agent tabun and the insecticide paraoxon together with nine symmetrical xylene-bridged compounds, was tested in vitro. Seven compounds were promising against paraoxon-inhibited AChE. Two compounds were found to be more potent against tabun-inhibited AChE than obidoxime at a concentration applicable in vivo. Nine potential non-symmetrical xylene-bridged AChE reactivators were synthesized using modifications of currently known synthetic pathways. Their potency to reactivate AChE inhibited by the nerve agent tabun and the insecticide paraoxon together with nine symmetrical xylene-bridged compounds, was tested in vitro. Seven compounds were promising against paraoxon-inhibited AChE. Two compounds were found to be more potent against tabun-inhibited AChE than obidoxime at a concentration applicable in vivo. (en) Byla přípravena nové série asymetrických bispyridiniových sloučenin s xylenovým spojovacím řetězcem a testování jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesterase. (cs)
Title	Příprava nové série asymetrických bispyridiniových sloučenin s xylenovým spojovacím řetězcem a testování jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesterase (cs) Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase (en)
skos:prefLabel	Příprava nové série asymetrických bispyridiniových sloučenin s xylenovým spojovacím řetězcem a testování jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesterase (cs) Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase (en)
skos:notation	RIV/60162694:G44__/07:00001767!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	425-432
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	453953
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001767
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; reactivation; nerve agent; tabun; pesticide; paraoxon; oxime (en)
http://linked.open.../riv/klicoveSlovo	pesticide acetylcholinesterase reactivation tabun paraoxon nerve agent oxime
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[25ACA0D564F4]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Doležal, Martin Dohnal, Vlastimil Kuča, Kamil Musílek, Kamil Jun, Daniel Holas, Ondřej
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1475-6366
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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