| Attributes | Values |
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| rdf:type
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| Description
| - Searching for new potent acetylcholinesterase (AChE; EC 3.1.1.7) reactivators (oximes) is a very time consuming process. At our department, we are able to synthesize more than 50 new AChE reactivators per year. Owing to this fact, we have to select promising reactivators using our in vitro method (potentiometric titration: pH 8, temperature 25°C; source of cholinesterases: rat brain homogenate; time of inhibition by nerve agents: 30 min; time of reactivation: 10 min) prior to in vivo experiments. For this purpose, we are using two-phase in vitro evaluation of reactivator potency. In the first phase, reactivation potency of all newly synthesized AChE reactivators is tested at two concentrations: 10-3 M and 10-5 M. Afterwards, all reactivators achieving reactivation potency over 10% (especially at the concentration 10-5 M) are tested. The second phase consists of the measurement of the relationship between concentration of the oxime and its reactivation ability. In most in all cases, the reactivation be
- Searching for new potent acetylcholinesterase (AChE; EC 3.1.1.7) reactivators (oximes) is a very time consuming process. At our department, we are able to synthesize more than 50 new AChE reactivators per year. Owing to this fact, we have to select promising reactivators using our in vitro method (potentiometric titration: pH 8, temperature 25°C; source of cholinesterases: rat brain homogenate; time of inhibition by nerve agents: 30 min; time of reactivation: 10 min) prior to in vivo experiments. For this purpose, we are using two-phase in vitro evaluation of reactivator potency. In the first phase, reactivation potency of all newly synthesized AChE reactivators is tested at two concentrations: 10-3 M and 10-5 M. Afterwards, all reactivators achieving reactivation potency over 10% (especially at the concentration 10-5 M) are tested. The second phase consists of the measurement of the relationship between concentration of the oxime and its reactivation ability. In most in all cases, the reactivation be (en)
- V této práci byly testovány strukturně odlišné reaktivátory acetylcholinesterázy pro svou schopnost reaktivovat tabunem inhibovanou acetylcholinetserázu. Všechny reaktivátory byly testovány screeningovou in vitro metodou. Následně byla testována závislost reaktivační aktivity na jejich koncentraci jen u slibných reaktivátorů AChE. (cs)
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| Title
| - In vitro hodnocení reaktivátorů acetylcholinesterázy jako potenciálních antidot proti otravě tabunem (cs)
- In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings
- In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings (en)
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| skos:prefLabel
| - In vitro hodnocení reaktivátorů acetylcholinesterázy jako potenciálních antidot proti otravě tabunem (cs)
- In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings
- In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings (en)
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| skos:notation
| - RIV/60162694:G44__/06:00001494!RIV07-MO0-G44_____
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/06:00001494
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - cholinesterase; nerve agent; oxime; reactivators; tabun (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Drug and Chemical Toxicology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Cabal, Jiří
- Hrabinová, Martina
- Kuča, Kamil
- Jun, Daniel
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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