About: Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

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About: Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bylo připraveno šest potenciálních reaktivátorů AChE a testováno na chlorpyrifosem inhibovaném enzymu. (cs) Three asymmetrical AChE reactivators with cyano-moiety and propane linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxon was tested in vitro and compared to pralidoxime, HI-6, obidoxime, K027, and K048. According to the results, three compounds seem to be promising against paraoxon-inhibited AChE. Better results were obtained for bisquaternary substances at least with one oxime group in position four. None of tested substances was able to satisfactorily reactivate tabun-inhibited AChE at concentration applicable for in vivo experiments. Three asymmetrical AChE reactivators with cyano-moiety and propane linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxon was tested in vitro and compared to pralidoxime, HI-6, obidoxime, K027, and K048. According to the results, three compounds seem to be promising against paraoxon-inhibited AChE. Better results were obtained for bisquaternary substances at least with one oxime group in position four. None of tested substances was able to satisfactorily reactivate tabun-inhibited AChE at concentration applicable for in vivo experiments. (en)
Title	Syntéza asymetrických bispyridiniových sloučenin s kyano skupinou a testování jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesterase (cs) Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. (en)
skos:prefLabel	Syntéza asymetrických bispyridiniových sloučenin s kyano skupinou a testování jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesterase (cs) Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. (en)
skos:notation	RIV/60162694:G44__/06:00001446!RIV07-MO0-G44_____
http://linked.open.../vavai/riv/strany	5673-5676
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	502820
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/06:00001446
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acetylcholinesterase; Reactivation; Nerve agent; Tabun; Pesticide; Paraoxon; Reactivator; Oxime (en)
http://linked.open.../riv/klicoveSlovo	Tabun Pesticide Reactivation Acetylcholinesterase Reactivator Paraoxon Nerve agent Oxime
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7A9F2627AF1B]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Doležal, Martin Dohnal, Vlastimil Kuča, Kamil Musílek, Kamil Jun, Daniel Holas, Ondřej
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0960-894X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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