About: Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs.

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About: Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Reactivation efficacy of three homologous and three isomeric series of pralidoxime-type reactivators with aldoxime group in position 2, 3 and 4 of the heterocycle was tested in reactivation of tabun-inhibited AChE. The experiments were performed with immobilized and stabilized porcine brain AChE. The enzyme activity was measured by Ellman method. Reactivation efficacy was determined by measurement of indicator fabric coloration intensity as a measure of AChE activity. Of the studied group of nine reactivators, isomers with the functional group in position 2 were the most effective. The highest value (30 %) for reactivation of inhibited AChE was found for 2 PAE after treatment for 15 min at concentration 0.5 mg.cm-3. The efficacy of the isomers decreased in the order ortho > para > meta. No marked effect on the efficacy of the reactivators was observed on prolongation of the reactivation time. The reactivators efficacy decreased with decreasing concentration of their solutions. Reactivation efficacy of three homologous and three isomeric series of pralidoxime-type reactivators with aldoxime group in position 2, 3 and 4 of the heterocycle was tested in reactivation of tabun-inhibited AChE. The experiments were performed with immobilized and stabilized porcine brain AChE. The enzyme activity was measured by Ellman method. Reactivation efficacy was determined by measurement of indicator fabric coloration intensity as a measure of AChE activity. Of the studied group of nine reactivators, isomers with the functional group in position 2 were the most effective. The highest value (30 %) for reactivation of inhibited AChE was found for 2 PAE after treatment for 15 min at concentration 0.5 mg.cm-3. The efficacy of the isomers decreased in the order ortho > para > meta. No marked effect on the efficacy of the reactivators was observed on prolongation of the reactivation time. The reactivators efficacy decreased with decreasing concentration of their solutions. (en)
Title	Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs. Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs. (en)
skos:prefLabel	Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs. Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs. (en)
skos:notation	RIV/60162694:G42__/10:00426916!RIV11-MO0-G42_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0UOPZHN0401)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kobliha, Zbyněk Hoskovcová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského leadershipu
http://linked.open...dnocenehoVysledku	283988
http://linked.open...ai/riv/idVysledku	RIV/60162694:G42__/10:00426916
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tabun; reactivation; pralidoxime (en)
http://linked.open.../riv/klicoveSlovo	pralidoxime reactivation tabun
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E3B0F249D73E]
http://linked.open...i/riv/nazevZdroje	Toxicology mechanisms and methods
http://linked.open...in/vavai/riv/obor	KA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Kobliha, Zbyněk Tušarová, Ivana Hoskovcová, Monika
http://linked.open...ain/vavai/riv/wos	000280310800001
http://linked.open...n/vavai/riv/zamer	Research of new methods and protection technologies against the effects of nuclear and chemical weapons
issn	1537-6516
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G42
is http://linked.open...avai/riv/vysledek of	Reactivation of immobilized acetylcholinesterase-tabun complex by pralidoxime, its isomers and homologs.

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