About: Genotoxic effects of soman and oxime HI-6: the induction of DNA

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genotoxický účinek somanu a HI-6 oximu: indukce DNA (cs) Soman applied i.m. at doses corresponding to 20% or 60% of LD50 did not induce DNA breaks, but only endonuclease III sensitive sites (representing oxidised pyrimidines or abasic sites) in the DNA of lymphocytes and liver cells of male MNRI mice and Chinese hamsters. Significant amount of micronuclei was induced also in polychromatophilic erythrocytes in bone marrow. Neither of these effects was found after application of same doses of sarin related to its toxicity in vivo. Intramuscular application of 2% or 20% LD50 HI-6 oxime induced single strand DNA breaks and endonuclease III sensitive sites. Micronuclei were induced as well. Results suggest that HI-6 oxime might be mildly genotoxic. Oxidative DNA damage might be induced by soman. Soman applied i.m. at doses corresponding to 20% or 60% of LD50 did not induce DNA breaks, but only endonuclease III sensitive sites (representing oxidised pyrimidines or abasic sites) in the DNA of lymphocytes and liver cells of male MNRI mice and Chinese hamsters. Significant amount of micronuclei was induced also in polychromatophilic erythrocytes in bone marrow. Neither of these effects was found after application of same doses of sarin related to its toxicity in vivo. Intramuscular application of 2% or 20% LD50 HI-6 oxime induced single strand DNA breaks and endonuclease III sensitive sites. Micronuclei were induced as well. Results suggest that HI-6 oxime might be mildly genotoxic. Oxidative DNA damage might be induced by soman. (en)
Title	Genotoxický účinek somanu a HI-6 oximu: indukce DNA (cs) Genotoxic effects of soman and oxime HI-6: the induction of DNA Genotoxic effects of soman and oxime HI-6: the induction of DNA (en)
skos:prefLabel	Genotoxický účinek somanu a HI-6 oximu: indukce DNA (cs) Genotoxic effects of soman and oxime HI-6: the induction of DNA Genotoxic effects of soman and oxime HI-6: the induction of DNA (en)
skos:notation	RIV/60162694:G38__/01:00000859!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany	35-37
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(MO66021299108)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Nečasová, Radka Štětina, Rudolf
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	681112
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/01:00000859
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	: Sarin, soman, HI-6, DNA breaks , comet assaySarin;soman;HI-6;DNA breaks;comet assay (en)
http://linked.open.../riv/klicoveSlovo	soman : Sarin DNA breaks DNA breaks comet assaySarin comet assay HI-6
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5A3F33C40E3B]
http://linked.open...i/riv/nazevZdroje	Vojenské zdravotnické listy - Suplementum
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The study of genotoxicity of sarin, soman and HI-6 oxime, and their influence on the effect of mutagenic and carcinogenic compounds
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	70
http://linked.open...iv/tvurceVysledku	Štětina, Rudolf Bárta, I. Šmerák, P. Nečasová, Radka
issn	0372-7025
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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