About: Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans     Goto   Sponge   NotDistinct   Permalink

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Description
  • Ukázali jsme, že jaderný receptor NHR-25, jehož ortology u drosofily a u savců jsou důležitými regulátory vývoje a pohlavní determinace, hraje kritickou roli v diferenciaci epidermis. Nedostatek NHR-25 zabraňuje epiteliálním kmenovým buňkám obnovovat jejich vzájemná spojení, která jsou dočasně přerušována asymetrickými děleními těchto buněk. Ztráta těchto mezibuněčných kontaktů vede k abnormální specifikaci osudu dceřinných buněk a k jejich nadpočetným dělením. Model C. elegans tak ukázal novou úlohu evolučně konservovaného jaderného receptoru na úrovni diferenciace jednotlivých buněk. (cs)
  • We show that a nuclear receptor NHR-25, whose Drosophila and mammalian orthologs are important regulators of development and sex determination, plays a critical role in epidermal differentiation. Deficiency of NHR-25 prevents epithelial stem cells to renew their adherens junction contacts, which are temporarily lost following asymmetric divisions of these cells. The lack of these cell-cell contacts results in abnormal fate specification of the stem cell daughters and in their excessive division. The C. elegans model reveals a new role for the evolutionarily conserved nuclear receptor with an individual cell resolution.
  • We show that a nuclear receptor NHR-25, whose Drosophila and mammalian orthologs are important regulators of development and sex determination, plays a critical role in epidermal differentiation. Deficiency of NHR-25 prevents epithelial stem cells to renew their adherens junction contacts, which are temporarily lost following asymmetric divisions of these cells. The lack of these cell-cell contacts results in abnormal fate specification of the stem cell daughters and in their excessive division. The C. elegans model reveals a new role for the evolutionarily conserved nuclear receptor with an individual cell resolution. (en)
Title
  • Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans
  • Jaderný receptor NHR-25 je nezbytný pro tvarové změny buněk během epidermální diferenciace u Caenorhabditis elegans (cs)
  • Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans (en)
skos:prefLabel
  • Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans
  • Jaderný receptor NHR-25 je nezbytný pro tvarové změny buněk během epidermální diferenciace u Caenorhabditis elegans (cs)
  • Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans (en)
skos:notation
  • RIV/60077409:_____/05:00025597!RIV06-GA0-60077409
http://linked.open.../vavai/riv/strany
  • 223;232
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GD524/03/H133), P(KJB5022303), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 533449
http://linked.open...ai/riv/idVysledku
  • RIV/60077409:_____/05:00025597
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Caenorhabditis elegans; nuclear receptor; epidermal stem cells (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [BB293E2F4E19]
http://linked.open...i/riv/nazevZdroje
  • Journal of Cell Science
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 118
http://linked.open...iv/tvurceVysledku
  • Jindra, Marek
  • Asahina, Masako
  • Šilhánková, Marie
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9533
number of pages
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