About: A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids.

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About: A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A relatively large nuclear-encoded polypeptide, designated trCOIV, is found in the cytochrome c oxidase (CO) complex of trypanosomatids. In order to determine if this polypeptide represents a bona fide subunit of the complex, we have characterized the cDNA and the gene for this polypeptide in Leishmania tarentolae. Its nuclear gene has no sequence similarity to mammalian COIV. The trCOIV preprotein has a long mitochondria targeting sequence of 31 residues. The mature polypeptide cofractionates with kinetoplast-mitochondria and its preferential mitochondria localization was confirmed by immunofluorescence and immunoelectron microscopy. Based on the hydropathy plot analysis, the protein lacks pronounced transmembrane domains and likely occupies a peripheral position within the CO complex. The corresponding genes are also present in the sequenced portions of the Trypanosoma cruzi, T. brucei and Leishmania major genomes, and the same polypeptide is found in cytochrome oxidase isolated from procyclic T. br A relatively large nuclear-encoded polypeptide, designated trCOIV, is found in the cytochrome c oxidase (CO) complex of trypanosomatids. In order to determine if this polypeptide represents a bona fide subunit of the complex, we have characterized the cDNA and the gene for this polypeptide in Leishmania tarentolae. Its nuclear gene has no sequence similarity to mammalian COIV. The trCOIV preprotein has a long mitochondria targeting sequence of 31 residues. The mature polypeptide cofractionates with kinetoplast-mitochondria and its preferential mitochondria localization was confirmed by immunofluorescence and immunoelectron microscopy. Based on the hydropathy plot analysis, the protein lacks pronounced transmembrane domains and likely occupies a peripheral position within the CO complex. The corresponding genes are also present in the sequenced portions of the Trypanosoma cruzi, T. brucei and Leishmania major genomes, and the same polypeptide is found in cytochrome oxidase isolated from procyclic T. br (en)
Title	A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids. A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids. (en)
skos:prefLabel	A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids. A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids. (en)
skos:notation	RIV/60077409:_____/02:59023056!RIV/2003/AV0/A59003/N
http://linked.open.../vavai/riv/strany	113;125
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/00/1212), Z(AV0Z6022909), Z(MSM 123100003)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Lukeš, Julius Zíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Parazitologický ústav AV ČR
http://linked.open...dnocenehoVysledku	637171
http://linked.open...ai/riv/idVysledku	RIV/60077409:_____/02:59023056
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytochrome c oxidase; mitochondrion; kinetoplast (en)
http://linked.open.../riv/klicoveSlovo	cytochrome c oxidase kinetoplast mitochondrion
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C16CD17CBD2D]
http://linked.open...i/riv/nazevZdroje	Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Evolution of kinetoplast DNA structure and RNA editing in primitive kinetoplastida
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	125
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Zíková, Alena Maslov, D. A. Kyselová, Iveta
http://linked.open...n/vavai/riv/zamer	Parazitické a symbiotické organismy živočichů a člověka: jejich vzájemné vztahy na úrovni populací, organismů, buněk a molekul http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20123100003
issn	0166-6851
number of pages	13 (xsd:int)

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