About: Smooth esterification of Di-and Tricarboxylic acids with methyl and ethyl chloroformates in gas chromatographic profiling of urinary acidic metabolites.

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About: Smooth esterification of Di-and Tricarboxylic acids with methyl and ethyl chloroformates in gas chromatographic profiling of urinary acidic metabolites. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Fast esterification of (di)carboxylic acids in aqueous pyridine-containing media with methyl or ethyl chloroformate is presented. The reaction conditions have been optimized to allow also determination of C4 (succinic) and C5 (glutaric) dicarboxylic acids and their substituents, i.e. the important urinary metabolites. Treated with chloroformates, these analytes commonly escape determination due to favouring internal cyclization to 5- and 6-membered rings of their parent anhydrides, prone to decomposition in the hot injection liner. To restore the diester formation, an alternative way of sample processing was developed. It was based on adding alcohol in excess and reagent in two portions, with applied time delay or neutralization of the first portion with hydroxide. This way, the di- and tricarboxylic acids of interest could be esterified effectively, some under formation of minor side-products. The novel approach proved to be quite suitable for screening urinary metabolites, without a necessity to pre Fast esterification of (di)carboxylic acids in aqueous pyridine-containing media with methyl or ethyl chloroformate is presented. The reaction conditions have been optimized to allow also determination of C4 (succinic) and C5 (glutaric) dicarboxylic acids and their substituents, i.e. the important urinary metabolites. Treated with chloroformates, these analytes commonly escape determination due to favouring internal cyclization to 5- and 6-membered rings of their parent anhydrides, prone to decomposition in the hot injection liner. To restore the diester formation, an alternative way of sample processing was developed. It was based on adding alcohol in excess and reagent in two portions, with applied time delay or neutralization of the first portion with hydroxide. This way, the di- and tricarboxylic acids of interest could be esterified effectively, some under formation of minor side-products. The novel approach proved to be quite suitable for screening urinary metabolites, without a necessity to pre (en)
Title	Smooth esterification of Di-and Tricarboxylic acids with methyl and ethyl chloroformates in gas chromatographic profiling of urinary acidic metabolites. Smooth esterification of Di-and Tricarboxylic acids with methyl and ethyl chloroformates in gas chromatographic profiling of urinary acidic metabolites. (en)
skos:prefLabel	Smooth esterification of Di-and Tricarboxylic acids with methyl and ethyl chloroformates in gas chromatographic profiling of urinary acidic metabolites. Smooth esterification of Di-and Tricarboxylic acids with methyl and ethyl chloroformates in gas chromatographic profiling of urinary acidic metabolites. (en)
skos:notation	RIV/60077395:_____/03:60033100!RIV/2004/AV0/A60004/N
http://linked.open.../vavai/riv/strany	623;630
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/01/1586), P(IPP1050128), Z(AV0Z5007907)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Šimek, Petr Hušek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Entomologický ústav AV ČR
http://linked.open...dnocenehoVysledku	627464
http://linked.open...ai/riv/idVysledku	RIV/60077395:_____/03:60033100
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gas chromatography; esterification with chloroformates (en)
http://linked.open.../riv/klicoveSlovo	gas chromatography esterification with chloroformates
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[E7A5D5BE4123]
http://linked.open...i/riv/nazevZdroje	Chromatographia
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Alkyl chloroformate-induced derivatization in sample preparation and analysis of compounds of biomedical and biological importance Dynamics of processes in living and inanimate matter
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Hušek, Petr Šimek, Petr Matucha, P.
http://linked.open...n/vavai/riv/zamer	The use of insects for quality assessment and possible management of the ecosystems in Central Europe
issn	0009-5893
number of pages	8 (xsd:int)

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