About: Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Paclitaxel is an important, recently introduced anti-neoplastic drug. Paclitaxel metabolites are virtually inactive in comparison with the parent drug. The study investigated whether phenolic antioxidants could inhibit metabolic inactivation sufficiently to increase paclitaxel effects. Cytochrome P450 (CYP)-catalysed metabolism of paclitaxel was investigated in rat and human liver microsomes. In rat microsomes, paclitaxel was metabolised mainly to C3'-hydroxypaclitaxel (C3'-OHP), less to C2-hydroxypaclitaxel (C2-OHP), di-hydroxypaclitaxel (di-OHP) and another monohydroxylated paclitaxel. In human liver microsomes, 6alpha-hydroxypaclitaxel (6alpha-OHP), formed by CYP2C8, was the main metabolite, while C3'-OHP, C2-OHP and another product different from di-OHP were minor metabolites, formed by CYP3A4. In individual human livers 6alpha-OHP was formed at 1.8-fold to 13-fold higher rates than C3'-OHP. Kinetic parameters (K-m and V-max) of production of various metabolites in rat and human liver microsomes r Paclitaxel is an important, recently introduced anti-neoplastic drug. Paclitaxel metabolites are virtually inactive in comparison with the parent drug. The study investigated whether phenolic antioxidants could inhibit metabolic inactivation sufficiently to increase paclitaxel effects. Cytochrome P450 (CYP)-catalysed metabolism of paclitaxel was investigated in rat and human liver microsomes. In rat microsomes, paclitaxel was metabolised mainly to C3'-hydroxypaclitaxel (C3'-OHP), less to C2-hydroxypaclitaxel (C2-OHP), di-hydroxypaclitaxel (di-OHP) and another monohydroxylated paclitaxel. In human liver microsomes, 6alpha-hydroxypaclitaxel (6alpha-OHP), formed by CYP2C8, was the main metabolite, while C3'-OHP, C2-OHP and another product different from di-OHP were minor metabolites, formed by CYP3A4. In individual human livers 6alpha-OHP was formed at 1.8-fold to 13-fold higher rates than C3'-OHP. Kinetic parameters (K-m and V-max) of production of various metabolites in rat and human liver microsomes r (en)
Title	Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. (en)
skos:prefLabel	Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. (en)
skos:notation	RIV/60077395:_____/03:60033099!RIV/2004/AV0/A60004/N
http://linked.open.../vavai/riv/strany	200;209
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IPP1050128), P(NL6715), P(NL7567), Z(AV0Z5007907), Z(MZ023795.0001)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Šimek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Entomologický ústav AV ČR
http://linked.open...dnocenehoVysledku	620225
http://linked.open...ai/riv/idVysledku	RIV/60077395:_____/03:60033099
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	paclitaxel; cytochrome P450; rat (en)
http://linked.open.../riv/klicoveSlovo	cytochrome P450 rat paclitaxel
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1CDD2D1AE222]
http://linked.open...i/riv/nazevZdroje	Naunyn-Schmiedebergs Archives of Pharmacology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of resistance of tumor cells lines and breast cancer to chemotherapy by taxanes and possibilities of intervention Effect of polyphenols and chelators on toxicity and effects of anthracyclines and taxanes Dynamics of processes in living and inanimate matter
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	368
http://linked.open...iv/tvurceVysledku	Šimek, Petr Gut, I. Horský, S. Václavíková, R.
http://linked.open...n/vavai/riv/zamer	The use of insects for quality assessment and possible management of the ecosystems in Central Europe STUDY OF INFECTIOUS,ENVIRNMENTAL AND BEHAVIORAL HEALTH RISKS AND METHODS OF THEIR PREVENTION
issn	0028-1298
number of pages	10 (xsd:int)

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software