About: The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases.

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About: The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Drosophila melanogaster Fork head and Bombyx mori SGF1/Fork head proteins are key regulators of tissue specific gene expression in the modified larval labial glands. Here we use the competitive electrophoretic mobility shift assay to create a detailed Fork head binding matrix and we investigate some unusual features of the Fork head interaction with DNA. We found that the Fork head-DNA interaction is context dependent-the binding specificity of the protein is partly determined by specific combinations of neighbouring bases. Although the total number of the sub-optimal dinucleotide steps is not high, the negative cooperation of neighbouring bases significantly contributes to the overall binding site specificity. Our results allow efficient recognition of insect Fork head binding sites and we show that the putative Fork head cognate elements preferentially accumulate in the near upstream region of genes abundantly expressed in the labial gland. (C) 2003 Elsevier Ltd. All rights reserved. The Drosophila melanogaster Fork head and Bombyx mori SGF1/Fork head proteins are key regulators of tissue specific gene expression in the modified larval labial glands. Here we use the competitive electrophoretic mobility shift assay to create a detailed Fork head binding matrix and we investigate some unusual features of the Fork head interaction with DNA. We found that the Fork head-DNA interaction is context dependent-the binding specificity of the protein is partly determined by specific combinations of neighbouring bases. Although the total number of the sub-optimal dinucleotide steps is not high, the negative cooperation of neighbouring bases significantly contributes to the overall binding site specificity. Our results allow efficient recognition of insect Fork head binding sites and we show that the putative Fork head cognate elements preferentially accumulate in the near upstream region of genes abundantly expressed in the labial gland. (C) 2003 Elsevier Ltd. All rights reserved. (en)
Title	The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases. The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases. (en)
skos:prefLabel	The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases. The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases. (en)
skos:notation	RIV/60077395:_____/03:60033089!RIV/2004/AV0/A60004/N
http://linked.open.../vavai/riv/strany	1145;1154
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/96/0153), P(KSK5052113), P(ME 176), Z(AV0Z5007907)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Mach, Václav Gaži, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Entomologický ústav AV ČR
http://linked.open...dnocenehoVysledku	604238
http://linked.open...ai/riv/idVysledku	RIV/60077395:_____/03:60033089
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila; bombys; Galleria (en)
http://linked.open.../riv/klicoveSlovo	Drosophila bombys Galleria
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4E3C5602F0FE]
http://linked.open...i/riv/nazevZdroje	Insect Biochemistry and Molecular Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20176 Structure, expression and interaction of the genome Control of Gene Expression in salivary glands of Drosophila melanogaster
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Mach, Václav Takiya, S. Gaži, Michal
http://linked.open...n/vavai/riv/zamer	The use of insects for quality assessment and possible management of the ecosystems in Central Europe
issn	0965-1748
number of pages	10 (xsd:int)

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