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Description
| - In most eukaryotes, telomeres consist of a short tandem repetitive DNA. Insect telomeres are constituted by a (TTAGG)n motif. Telomeres are maintained by telomerase, a specialized reverse transcriptase that adds this sequence to chromosome ends. We examined telomerase activity in 15 species across Insecta. We found telomerase activity in phylogenetically distant species and we conclude a distribution pattern of (TTAGG)n is generally consistent with telomerase activity. Thus, the TTAGG-telomerase system is functional across the Insecta. Using real-time quantitative telomeric repeat amplification protocol (RTQ-TRAP), we quantified telomerase activity in different developmental stages and tissues of Periplaneta americana. Telomerase is upregulated in young instars and gradually declines during development; in adults most active in testes and ovaries. Thus, the telomerase activity of hemimetabolous insects seems to be associated with cell proliferation and organismal development.
- In most eukaryotes, telomeres consist of a short tandem repetitive DNA. Insect telomeres are constituted by a (TTAGG)n motif. Telomeres are maintained by telomerase, a specialized reverse transcriptase that adds this sequence to chromosome ends. We examined telomerase activity in 15 species across Insecta. We found telomerase activity in phylogenetically distant species and we conclude a distribution pattern of (TTAGG)n is generally consistent with telomerase activity. Thus, the TTAGG-telomerase system is functional across the Insecta. Using real-time quantitative telomeric repeat amplification protocol (RTQ-TRAP), we quantified telomerase activity in different developmental stages and tissues of Periplaneta americana. Telomerase is upregulated in young instars and gradually declines during development; in adults most active in testes and ovaries. Thus, the telomerase activity of hemimetabolous insects seems to be associated with cell proliferation and organismal development. (en)
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Title
| - Distribution of TTAGG-specific telomerase activity in insects
- Distribution of TTAGG-specific telomerase activity in insects (en)
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skos:prefLabel
| - Distribution of TTAGG-specific telomerase activity in insects
- Distribution of TTAGG-specific telomerase activity in insects (en)
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skos:notation
| - RIV/60077344:_____/14:00437284!RIV15-GA0-60077344
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/14:00437284
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Insects; telomere; telomerase (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Korandová, M.
- Čapková Frydrychová, Radmila
- Krůček, Tomáš
- Vrbová, K.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1007/s10577-014-9436-6
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