About: Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cryptosporidium ubiquitum is an emerging zoonotic pathogen. In the past, it was not possible to identify an association between cases of human and animal infection. We conducted a genomic survey of the species, developed a subtyping tool targeting the 60-kDa glycoprotein (gp60) gene, and identified 6 subtype families (XIIa-XIIf) of C. ubiquitum. Host adaptation was apparent at the gp60 locus; subtype XIIa was found in ruminants worldwide, subtype families XIIb-XIId were found in rodents in the United States, and XIIe and XIIf were found in rodents in the Slovak Republic. Humans in the United States were infected with isolates of subtypes XIIb-XIId, whereas those in other areas were infected primarily with subtype XIIa isolates. In addition, subtype families XIIb and XIId were detected in drinking source water in the United States. Contact with C. ubiquitum-infected sheep and drinking water contaminated by infected wildlife could be sources of human infections. Cryptosporidium ubiquitum is an emerging zoonotic pathogen. In the past, it was not possible to identify an association between cases of human and animal infection. We conducted a genomic survey of the species, developed a subtyping tool targeting the 60-kDa glycoprotein (gp60) gene, and identified 6 subtype families (XIIa-XIIf) of C. ubiquitum. Host adaptation was apparent at the gp60 locus; subtype XIIa was found in ruminants worldwide, subtype families XIIb-XIId were found in rodents in the United States, and XIIe and XIIf were found in rodents in the Slovak Republic. Humans in the United States were infected with isolates of subtypes XIIb-XIId, whereas those in other areas were infected primarily with subtype XIIa isolates. In addition, subtype families XIIb and XIId were detected in drinking source water in the United States. Contact with C. ubiquitum-infected sheep and drinking water contaminated by infected wildlife could be sources of human infections. (en)
Title	Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans (en)
skos:prefLabel	Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans (en)
skos:notation	RIV/60077344:_____/14:00429417!RIV15-AV0-60077344
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(LH11061)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Sak, Bohumil Kváč, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	48483
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/14:00429417
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cervine genotype; source tracking; small mammals (en)
http://linked.open.../riv/klicoveSlovo	small mammals cervine genotype source tracking
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0DF15A01D457]
http://linked.open...i/riv/nazevZdroje	Emerging Infectious Diseases
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	Diversity, biology and phylogeny of Cryptosporidium spp. parasiting in rodents
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Kváč, Martin Li, N. Sak, Bohumil Fayer, R. Feng, Y. Zhang, L. Wang, L. Guo, Y. Stanko, M. Alderisio, K. Cai, J. Cebelinski, E. Chalmers, R. Elwin, K. Roellig, D. Ryan, U. Santin, M.
http://linked.open...ain/vavai/riv/wos	000330553800006
issn	1080-6040
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.3201/eid2002.121797

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