About: Molecular phylogeography of tick-borne encephalitis virus in central Europe

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of two main lineages, A and B. In contrast to the east to west spread at the Eurasian continent level, local central European spreading patterns suggest historic west to east spread followed by more recent east to west spread. The phylogenetic and network analyses indicate TBEV ingressions from the Czech Republic and Slovakia into Germany via landscape features (Danube river system), biogenic factors (birds, red deer) and anthropogenic factors. The identification of endemic foci showing local genetic diversity is of paramount importance to the field as these will be a prerequisite for in-depth analysis of focal TBEV maintenance and long-distance TBEV spread. In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of two main lineages, A and B. In contrast to the east to west spread at the Eurasian continent level, local central European spreading patterns suggest historic west to east spread followed by more recent east to west spread. The phylogenetic and network analyses indicate TBEV ingressions from the Czech Republic and Slovakia into Germany via landscape features (Danube river system), biogenic factors (birds, red deer) and anthropogenic factors. The identification of endemic foci showing local genetic diversity is of paramount importance to the field as these will be a prerequisite for in-depth analysis of focal TBEV maintenance and long-distance TBEV spread. (en)
Title	Molecular phylogeography of tick-borne encephalitis virus in central Europe Molecular phylogeography of tick-borne encephalitis virus in central Europe (en)
skos:prefLabel	Molecular phylogeography of tick-borne encephalitis virus in central Europe Molecular phylogeography of tick-borne encephalitis virus in central Europe (en)
skos:notation	RIV/60077344:_____/13:00421268!RIV14-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED0006/01/01), P(GAP502/11/2116)
http://linked.open...iv/cisloPeriodika	SEP 2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Růžek, Daniel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	89326
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00421268
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ixodes ricinus ticks; Dermacentor reticulatus; purifying selection (en)
http://linked.open.../riv/klicoveSlovo	Ixodes ricinus ticks Dermacentor reticulatus purifying selection
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E2A8902F718E]
http://linked.open...i/riv/nazevZdroje	Journal of General Virology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine Differences in clinical course of tick-borne encephalitis in host, and their genetic determination
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	94
http://linked.open...iv/tvurceVysledku	Růžek, Daniel Pfeffer, M. Vogerl, M. Dobler, G. Essbauer, S. Hufert, F.T. Weidmann, M. Zanotto, P. M. de A. Klempa, B. Freire, C. C. M. Frey, S. Zubrikova, D.
http://linked.open...ain/vavai/riv/wos	000326304600020
issn	0022-1317
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1099/vir.0.054478-0

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