About: Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores

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About: Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study an in vitro assay was used to determine the importance of Ca2 + stores and the involvement of PKC and cAMP pathways by which AKH exerts its anti-oxidative effects. 4-HNE was significantly enhanced and membrane fluidity reduced in the CNS of P. apterus when treated with H2O2. These biomarkers of OS were reduced when H2O2 was co-treated with AKH. The healing effect of AKH was negated in the presence of Ca2 + channel inhibitors. Presence of inhibitors of PKC compromised the anti-oxidative function of AKH. Presence of PKC or cAMP activators restored the protective effects of AKH treatment. Our results implicate the importance of Ca2 + stores, PKC and cAMP pathways in AKHs' anti-oxidative action. In this study an in vitro assay was used to determine the importance of Ca2 + stores and the involvement of PKC and cAMP pathways by which AKH exerts its anti-oxidative effects. 4-HNE was significantly enhanced and membrane fluidity reduced in the CNS of P. apterus when treated with H2O2. These biomarkers of OS were reduced when H2O2 was co-treated with AKH. The healing effect of AKH was negated in the presence of Ca2 + channel inhibitors. Presence of inhibitors of PKC compromised the anti-oxidative function of AKH. Presence of PKC or cAMP activators restored the protective effects of AKH treatment. Our results implicate the importance of Ca2 + stores, PKC and cAMP pathways in AKHs' anti-oxidative action. (en)
Title	Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores (en)
skos:prefLabel	Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores (en)
skos:notation	RIV/60077344:_____/13:00395099!RIV14-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P V
http://linked.open...avai/riv/aktivity	I, P(GAP501/10/1215), V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bednářová, Andrea Kodrík, Dalibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	59560
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00395099
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adipokinetic hormone; calcium channel; cell signaling (en)
http://linked.open.../riv/klicoveSlovo	adipokinetic hormone calcium channel cell signaling
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CC15663A7571]
http://linked.open...i/riv/nazevZdroje	Comparative Biochemistry and Physiology Part C
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Stress hormones and their potential usage in insect pest control
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	158
http://linked.open...iv/tvurceVysledku	Kodrík, Dalibor Krishnan, N. Bednářová, Andrea
http://linked.open...ain/vavai/riv/wos	000325907700002
issn	1532-0456
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cbpc.2013.07.002

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