About: Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster

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About: Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0016648013002621
Description	Drosophila FMRF-related neuropeptides are functionally unrelated peptides targeting different organs, with different effective thresholds, time-course and expression patterns. They were all suggested to have an effect on the locomotor activity of Drosophila adults. We prepared RNAi knockdowns of the peptides and their specific receptor genes as well as ablated FMRF-positive neurons by inducing apoptosis using the reaper (rpr) gene expression. We show that RNAi silencing of the FaRP and FaRP-receptor genes effectively decreased the startle-induced locomotor activity of flies. Consistantly, the ablation of FMRF-positive neurons by the RS8-Gal4 and/or RS17-Gal4 drivers also significantly decreased fly locomotion. Drosophila FMRF-related neuropeptides are functionally unrelated peptides targeting different organs, with different effective thresholds, time-course and expression patterns. They were all suggested to have an effect on the locomotor activity of Drosophila adults. We prepared RNAi knockdowns of the peptides and their specific receptor genes as well as ablated FMRF-positive neurons by inducing apoptosis using the reaper (rpr) gene expression. We show that RNAi silencing of the FaRP and FaRP-receptor genes effectively decreased the startle-induced locomotor activity of flies. Consistantly, the ablation of FMRF-positive neurons by the RS8-Gal4 and/or RS17-Gal4 drivers also significantly decreased fly locomotion. (en)
Title	Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster (en)
skos:prefLabel	Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster (en)
skos:notation	RIV/60077344:_____/13:00394182!RIV14-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	SEP 15
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kakaš, Štefan Žurovec, Michal Šerý, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	104529
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00394182
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila melanogaster; FMRF-related peptides; G protein-coupled receptors (en)
http://linked.open.../riv/klicoveSlovo	FMRF-related peptides G protein-coupled receptors Drosophila melanogaster
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B434CC32E1B6]
http://linked.open...i/riv/nazevZdroje	General and Comparative Endocrinology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	191
http://linked.open...iv/tvurceVysledku	Žurovec, Michal Šerý, Michal Kiss, I. Fónagy, A. Hegedűs, Z. Kakaš, Štefan Kiss, B. Lukacsovich, T. Puskás, L. Ramasz, B. Szlanka, T. Zvara, Á.
http://linked.open...ain/vavai/riv/wos	000323870400015
issn	0016-6480
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ygcen.2013.05.023

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