About: Evolution and metabolic significance of the urea cycle in photosynthetic diatoms

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	RNA-interference-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nitrogen-limited diatoms to nitrogen addition. Intermediates in the ornithine-urea cycle are particularly depleted and both the tricarboxylic acid cycle and the glutamine synthetase/glutamate synthase cycles are linked directly with the ornithine-urea cycle. Several other metabolites are generated from this cycle by products of genes acquired from bacteria. So far, this cycle is only known for its essential role in the removal of fixed nitrogen in metazoans. In diatoms, this cycle serves as a distribution and repackaging hub for inorganic carbon and nitrogen and contributes significantly to the metabolic response of diatoms to episodic nitrogen availability. The diatomornithine-urea cycle therefore represents a key pathway for anaplerotic carbon fixation into nitrogenous compounds that are essential for diatom growth and for the contribution of diatoms to marine productivity. RNA-interference-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nitrogen-limited diatoms to nitrogen addition. Intermediates in the ornithine-urea cycle are particularly depleted and both the tricarboxylic acid cycle and the glutamine synthetase/glutamate synthase cycles are linked directly with the ornithine-urea cycle. Several other metabolites are generated from this cycle by products of genes acquired from bacteria. So far, this cycle is only known for its essential role in the removal of fixed nitrogen in metazoans. In diatoms, this cycle serves as a distribution and repackaging hub for inorganic carbon and nitrogen and contributes significantly to the metabolic response of diatoms to episodic nitrogen availability. The diatomornithine-urea cycle therefore represents a key pathway for anaplerotic carbon fixation into nitrogenous compounds that are essential for diatom growth and for the contribution of diatoms to marine productivity. (en)
Title	Evolution and metabolic significance of the urea cycle in photosynthetic diatoms Evolution and metabolic significance of the urea cycle in photosynthetic diatoms (en)
skos:prefLabel	Evolution and metabolic significance of the urea cycle in photosynthetic diatoms Evolution and metabolic significance of the urea cycle in photosynthetic diatoms (en)
skos:notation	RIV/60077344:_____/11:00359538!RIV12-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA206/08/1423), S, Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	7346
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Oborník, Miroslav Horák, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	198479
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00359538
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CARBAMOYL-PHOSPHATE SYNTHETASE; PHAEODACTYLUM-TRICORNUTUM; MAXIMUM-LIKELIHOOD; PHYLOGENETIC RECONSTRUCTION; MOLECULAR EVOLUTION; SEQUENCE ALIGNMENT; DIVERGENCE TIMES; MARINE DIATOMS; MIXED MODELS; TREE (en)
http://linked.open.../riv/klicoveSlovo	CARBAMOYL-PHOSPHATE SYNTHETASE DIVERGENCE TIMES MARINE DIATOMS MIXED MODELS MOLECULAR EVOLUTION PHAEODACTYLUM-TRICORNUTUM PHYLOGENETIC RECONSTRUCTION SEQUENCE ALIGNMENT TREE MAXIMUM-LIKELIHOOD
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[423BAC231543]
http://linked.open...i/riv/nazevZdroje	Nature
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Heme Biosynthesis in Euglenozoa
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	473
http://linked.open...iv/tvurceVysledku	Horák, Aleš Allen, A. E. Bowler, Ch. Dupont, Ch. L. Fernie, A. R. Hu, H. Johnson, D. A. McCrow, J. P. Nunes-Nesi, A. Oborník, Miroslav Zheng, H.
http://linked.open...ain/vavai/riv/wos	000290487200036
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0028-0836
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/nature10074
is http://linked.open...avai/riv/vysledek of	Evolution and metabolic significance of the urea cycle in photosynthetic diatoms Evolution and metabolic significance of the urea cycle in photosynthetic diatoms

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