About: Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections

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About: Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis. The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis. (en)
Title	Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections (en)
skos:prefLabel	Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections (en)
skos:notation	RIV/60077344:_____/11:00359447!RIV12-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(KJB500960701), V, Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kodádková, Alena Salát, Jiří Sak, Bohumil Květoňová, Dana Kváč, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	184491
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00359447
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CD4+T-lymphocytes; CD8+T-lymphocytes; Cryptosporidium muris; T-cell-mediated immunity (en)
http://linked.open.../riv/klicoveSlovo	CD4+T-lymphocytes CD8+T-lymphocytes Cryptosporidium muris T-cell-mediated immunity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9D0144659169]
http://linked.open...i/riv/nazevZdroje	Parasite immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Immune response of mice to infection with different gastric cryptosporidia from mammals
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Jalovecká, M. Kodádková, Alena Kváč, Martin Květoňová, Dana Rost, M. Salát, Jiří Sak, Bohumil
http://linked.open...ain/vavai/riv/wos	000288249400002
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0141-9838
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1365-3024.2010.01271.x
is http://linked.open...avai/riv/vysledek of	Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections

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