About: Phylogenetic and Virulence Analysis of Tick-Borne Encephalitis Virus Field Isolates From Switzerland

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tick-borne encephalitis (TBE) is an endemic disease in Switzerland, with about 110-120 reported human cases each year. In this study, the complete envelope (E) protein sequences and phylogenetic classification of 72 TBE viruses found in Ixodes ricinus ticks sampled at 39 foci throughout Switzerland were analyzed. All isolates belonged to the European subtype and were highly. Sixty-four isolates were characterized in vitro with respect to their plaque phenotype. All of six virus isolates investigated in an in vivo mouse model were highly neurovirulent (100% mortality) but exhibited a relatively low level of neuroinvasiveness, with mouse survival rates ranging from 50% to 100%. Therefore, TBE viruses circulating in Switzerland belong to the European subtype and are closely related. In vitro and in vivo surrogates suggest a high proportion of isolates with a relatively low level of virulence, which is in agreement with a hypothesized high proportion of subclinical or mild TBE infections. Tick-borne encephalitis (TBE) is an endemic disease in Switzerland, with about 110-120 reported human cases each year. In this study, the complete envelope (E) protein sequences and phylogenetic classification of 72 TBE viruses found in Ixodes ricinus ticks sampled at 39 foci throughout Switzerland were analyzed. All isolates belonged to the European subtype and were highly. Sixty-four isolates were characterized in vitro with respect to their plaque phenotype. All of six virus isolates investigated in an in vivo mouse model were highly neurovirulent (100% mortality) but exhibited a relatively low level of neuroinvasiveness, with mouse survival rates ranging from 50% to 100%. Therefore, TBE viruses circulating in Switzerland belong to the European subtype and are closely related. In vitro and in vivo surrogates suggest a high proportion of isolates with a relatively low level of virulence, which is in agreement with a hypothesized high proportion of subclinical or mild TBE infections. (en)
Title	Phylogenetic and Virulence Analysis of Tick-Borne Encephalitis Virus Field Isolates From Switzerland Phylogenetic and Virulence Analysis of Tick-Borne Encephalitis Virus Field Isolates From Switzerland (en)
skos:prefLabel	Phylogenetic and Virulence Analysis of Tick-Borne Encephalitis Virus Field Isolates From Switzerland Phylogenetic and Virulence Analysis of Tick-Borne Encephalitis Virus Field Isolates From Switzerland (en)
skos:notation	RIV/60077344:_____/11:00359444!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GPP302/10/P438), P(LC06009), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Růžek, Daniel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	220315
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00359444
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	molecular epidemiology; envelope protein; neuroinvasiveness/virulence; European subtype; Ixodes ricinus (en)
http://linked.open.../riv/klicoveSlovo	Ixodes ricinus molecular epidemiology European subtype envelope protein neuroinvasiveness/virulence
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BB2A24179937]
http://linked.open...i/riv/nazevZdroje	Journal of Medical Virology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Role of the blood-brain barrier in tick-borne encephalitis neuropathogenesis
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	83
http://linked.open...iv/tvurceVysledku	Růžek, Daniel Beuret, C. M. Gaumann, R. Muhlemann, K. Strasser, M.
http://linked.open...ain/vavai/riv/wos	000288464400016
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0146-6615
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jmv.21993
is http://linked.open...avai/riv/vysledek of	Phylogenetic and Virulence Analysis of Tick-Borne Encephalitis Virus Field Isolates From Switzerland

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