About: The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

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About: The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclear receptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronic genes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of a nuclear receptor interaction with the heterochrony pathway. Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclear receptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronic genes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of a nuclear receptor interaction with the heterochrony pathway. (en)
Title	The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition (en)
skos:prefLabel	The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition (en)
skos:notation	RIV/60077344:_____/10:00347271!RIV11-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0948), P(GD204/09/H058), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Asahina, Masako
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	275556
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00347271
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apl-1; Caenorhabditis elegans; heterochronic gene; heterochronic gene; let-7; nuclear receptor; nhr-25 (en)
http://linked.open.../riv/klicoveSlovo	nuclear receptor Caenorhabditis elegans apl-1 heterochronic gene let-7 nhr-25
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6EEA35155D5D]
http://linked.open...i/riv/nazevZdroje	Developmental Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Intercellular signalling in development and disease Crosstalk between nuclear receptor and Wnt signaling in C. elegans
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	344
http://linked.open...iv/tvurceVysledku	Hasegawa, H. Asahina, Masako Hada, K. Kanaho, Y. Niwa, R. Slack, F. J.
http://linked.open...ain/vavai/riv/wos	000280787100049
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0012-1606
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

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