About: CD8+ T-cells mediate immunopathology in tick-borne encephalitis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection. Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection. (en)
Title	CD8+ T-cells mediate immunopathology in tick-borne encephalitis CD8+ T-cells mediate immunopathology in tick-borne encephalitis (en)
skos:prefLabel	CD8+ T-cells mediate immunopathology in tick-borne encephalitis CD8+ T-cells mediate immunopathology in tick-borne encephalitis (en)
skos:notation	RIV/60077344:_____/09:00334945!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/08/1509), P(LC06009), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kopecký, Jan Grubhoffer, Libor Růžek, Daniel Salát, Jiří Dyková, Iva Jelínek, Jiří Fialová, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	306179
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00334945
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick-borne encephalitis; immunopathology; encephalitis (en)
http://linked.open.../riv/klicoveSlovo	tick-borne encephalitis immunopathology encephalitis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2F567E34128D]
http://linked.open...i/riv/nazevZdroje	Virology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Molecular pathogenesis of tick-borne encephalitis
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	384
http://linked.open...iv/tvurceVysledku	Dyková, Iva Grubhoffer, Libor Jelínek, Jiří Kopecký, Jan Růžek, Daniel Salát, Jiří Palus, M. Skallová, Anna Gould, E. A. Gritsun, T. S.
http://linked.open...ain/vavai/riv/wos	000263039200001
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0042-6822
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	CD8+ T-cells mediate immunopathology in tick-borne encephalitis CD8+ T-cells mediate immunopathology in tick-borne encephalitis CD8+ T-cells mediate immunopathology in tick-borne encephalitis CD8+ T-cells mediate immunopathology in tick-borne encephalitis

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