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| rdf:type
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| Description
| - Úloha interferonu gama (IFN-γ) v léčbě mikrosporidiózy působené druhem Encephalitozoon cuniculi byla studována pomocí adoptivních přenosů imunity a aplikací IFN-γ do SCID myší. Prokázali jsme, že adoptivní transfer CD4+ T lymfocytů z imunokopentencích myší prodloužil střední dobu přežití infikovaných SCID myší, naproti tomu přenos CD4+ T lymfocytů z myší neschopných produkovat IFN-γ neměl vliv na délku přežití. Projektivní úloha IFN-γ byla následně potvrzena cytokinovou terapií. Infikované SCID myši, kterým byl podáván IFN-γ přežívaly statisticky významně déle než myši neléčené. Současné podávání specifických anti-E. cuniculi protilátek zvyšovalo pozitivní vliv na přežívání myší. Na základě uvedených výsledků navrhujeme možné použití IFN-γ jako cytokinové terapie na léčbu mikrosporidiózy, zejména v případě CD4+ deficientních pacientů. (cs)
- The efficacy of gamma interferon (IFN-gamma) for the treatment of microsporidiosis caused by Encephalitozoon cuniculi was studied by means of adoptive transfer and IFN-gamma administration in SCID mice. While the adoptive transfer of CD4+ T cells from immunocompetent mice prolonged survival of SCID mice infected perorally with E. cuniculi, survival was not improved by adoptive transfer of CD4+ T lymphocytes from IFN-gamma-deficient mice. The protective effect of IFN-gamma was confirmed in cytokine therapy experiments in which SCID mice receiving IFN-gamma survived significantly longer than mice receiving mock injections. The administration of serum containing specific antibodies against E. cuniculi was found to prolong the survival of concurrently IFN-gamma-treated SCID mice. The data presented in this study suggest that IFN-gamma is potentially useful as a cytokine therapy for microsporidiosis, especially in CD4(+) T-cell-deficient patients.
- The efficacy of gamma interferon (IFN-gamma) for the treatment of microsporidiosis caused by Encephalitozoon cuniculi was studied by means of adoptive transfer and IFN-gamma administration in SCID mice. While the adoptive transfer of CD4+ T cells from immunocompetent mice prolonged survival of SCID mice infected perorally with E. cuniculi, survival was not improved by adoptive transfer of CD4+ T lymphocytes from IFN-gamma-deficient mice. The protective effect of IFN-gamma was confirmed in cytokine therapy experiments in which SCID mice receiving IFN-gamma survived significantly longer than mice receiving mock injections. The administration of serum containing specific antibodies against E. cuniculi was found to prolong the survival of concurrently IFN-gamma-treated SCID mice. The data presented in this study suggest that IFN-gamma is potentially useful as a cytokine therapy for microsporidiosis, especially in CD4(+) T-cell-deficient patients. (en)
|
| Title
| - Efficacy of gamma interferon and specific antibody for treatment of microsporidiosis caused by Encephalitozoon cuniculi in SCID mice
- Efficacy of gamma interferon and specific antibody for treatment of microsporidiosis caused by Encephalitozoon cuniculi in SCID mice (en)
- Účinnost interferonu gama a specifických protilátek v léčbě mikrosporidiózy způsobené druhem Encephalitozoon cuniculi na modelu SCID myší (cs)
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| skos:prefLabel
| - Efficacy of gamma interferon and specific antibody for treatment of microsporidiosis caused by Encephalitozoon cuniculi in SCID mice
- Efficacy of gamma interferon and specific antibody for treatment of microsporidiosis caused by Encephalitozoon cuniculi in SCID mice (en)
- Účinnost interferonu gama a specifických protilátek v léčbě mikrosporidiózy způsobené druhem Encephalitozoon cuniculi na modelu SCID myší (cs)
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| skos:notation
| - RIV/60077344:_____/08:00318363!RIV09-GA0-60077344
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GP524/03/D167), P(LC06009), Z(AV0Z60220518), Z(MSM 123100003)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/08:00318363
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - murine peritoneal-macrophages; IFN-gamma; immune-response; T-lymphocytes; infection; cells; therapy; AIDS; CD4+ (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Antimicrobial Agents and Chemotherapy
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Chmelař, Jindřich
- Jelínek, Jiří
- Kopecký, Jan
- Salát, Jiří
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| is http://linked.open...avai/riv/vysledek
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