About: AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY

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About: AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In PET, alpha-methyl amino acids can play a dual role: a) precursors of neurotransmitters analogues for the study of neurodegenerative diseases; b) non-metabolised analogues of proteinogenic amino acids for the study of amino acids uptake into normal and cancer cells. The difference in the uptake rates during a PET scan could visualise cancer cells in a human body. Clinical applications of such amino acids are strongly limited due to their poor availability. For the synthesis of alpha-[C-11]methyltryptophan, an industrial procedure was adopted. All attempts to prepare enantiomerically pure alpha[C-11]methylated tyrosine failed. We carried out [C-11] methylation of metalocomplex synthons derived from protected DOPA or tyrosine. Individual diastereomers were successfully separated by preparative HPLC, diluted with excess of water and extracted on C-18 cartridges. Optimisation of the procedure followed by hydrolysis of the complexes and purification of the enantiomers of alpha[C-11] methylDOPA and alpha- In PET, alpha-methyl amino acids can play a dual role: a) precursors of neurotransmitters analogues for the study of neurodegenerative diseases; b) non-metabolised analogues of proteinogenic amino acids for the study of amino acids uptake into normal and cancer cells. The difference in the uptake rates during a PET scan could visualise cancer cells in a human body. Clinical applications of such amino acids are strongly limited due to their poor availability. For the synthesis of alpha-[C-11]methyltryptophan, an industrial procedure was adopted. All attempts to prepare enantiomerically pure alpha[C-11]methylated tyrosine failed. We carried out [C-11] methylation of metalocomplex synthons derived from protected DOPA or tyrosine. Individual diastereomers were successfully separated by preparative HPLC, diluted with excess of water and extracted on C-18 cartridges. Optimisation of the procedure followed by hydrolysis of the complexes and purification of the enantiomers of alpha[C-11] methylDOPA and alpha- (en)
Title	AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY (en)
skos:prefLabel	AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY (en)
skos:notation	RIV/60076658:12640/06:00010093!RIV10-MSM-12640___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6007665808)
http://linked.open...iv/cisloPeriodika	suppl.4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Popkov, Alexandr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Ústav fyzikální biologie
http://linked.open...dnocenehoVysledku	464773
http://linked.open...ai/riv/idVysledku	RIV/60076658:12640/06:00010093
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	positron emission tomography; PET (en)
http://linked.open.../riv/klicoveSlovo	PET positron emission tomography
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A1A5300F369C]
http://linked.open...i/riv/nazevZdroje	Czechoslovak Journal of Physics
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Kožíšek, J. Lyčka, A. Breza, M. Popkov, Alexandr Nádvorník, M. Jirman, J. Weidlich, T. Gillings, N. M. Kružberská, P. Lehel, S.
http://linked.open...ain/vavai/riv/wos	000206057500085
http://linked.open...n/vavai/riv/zamer	Fyzikální biologie -nové přístupy v biologickém výzkumu
issn	0011-4626
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	12640
is http://linked.open...avai/riv/vysledek of	AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY

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