| Attributes | Values |
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| rdf:type
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| rdfs:seeAlso
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| Description
| - Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the few studies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tsh beta and slc5a5 was not significantly changed in our study. Besides, the THs levels increased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Hg2+ could alter some genes expression in the HPT axis which could be used as the potential biomarkers for evaluating the environmental Hg2+-induced stress in fish.
- Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the few studies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tsh beta and slc5a5 was not significantly changed in our study. Besides, the THs levels increased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Hg2+ could alter some genes expression in the HPT axis which could be used as the potential biomarkers for evaluating the environmental Hg2+-induced stress in fish. (en)
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| Title
| - Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride
- Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride (en)
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| skos:prefLabel
| - Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride
- Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride (en)
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| skos:notation
| - RIV/60076658:12520/14:43886815!RIV15-MSM-12520___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(ED2.1.00/01.0024), P(LO1205)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60076658:12520/14:43886815
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Gene expression; Hypothalamic-pituitary-thyroid axis; Thyroid hormone; Chinese rare minnow; Mercury (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Environmental Toxicology and Pharmacology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Li, Ping
- Li, Zhihua
- Chen, Lu
- Li, Yun-Feng
- Ni, Zhao-Hui
- Wu, Yan-Hua
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.etap.2014.07.002
|
| http://localhost/t...ganizacniJednotka
| |
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