About: Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem-loop IV domain, which is involved in both catalysis and RNP assembly, and includes binding sites for both the holoenzyme assembly protein p65 and telomerase reverse transcriptase (TERT). Stem-loop IV contains two regions with high evolutionary sequence conservation: a central GA bulge between helices, and a terminal loop. We solved the solution structure of loop IV and modeled the structure of the helical region containing the GA bulge, using NMR and residual dipolar couplings. The central GA bulge with flanking C-G base pairs induces a 50° semi-rigid bend in the helix. Loop IV is highly structured, and contains a conserved C-U base pair at the top of the helical stem. Analysis of new and previous biochemical data in light of the structure provides a rationale for some of the sequence conservation in this region of TER. The results suggest that during h Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem-loop IV domain, which is involved in both catalysis and RNP assembly, and includes binding sites for both the holoenzyme assembly protein p65 and telomerase reverse transcriptase (TERT). Stem-loop IV contains two regions with high evolutionary sequence conservation: a central GA bulge between helices, and a terminal loop. We solved the solution structure of loop IV and modeled the structure of the helical region containing the GA bulge, using NMR and residual dipolar couplings. The central GA bulge with flanking C-G base pairs induces a 50° semi-rigid bend in the helix. Loop IV is highly structured, and contains a conserved C-U base pair at the top of the helical stem. Analysis of new and previous biochemical data in light of the structure provides a rationale for some of the sequence conservation in this region of TER. The results suggest that during h (en) Studium elementů struktury vlásenky IV telomerázové RNA z Tetrahymeny důležitých pro funkci. (cs)
Title	Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function (en) Studium elementů struktury vlásenky IV telomerázové RNA z Tetrahymeny důležitých pro funkci. (cs)
skos:prefLabel	Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function (en) Studium elementů struktury vlásenky IV telomerázové RNA z Tetrahymeny důležitých pro funkci. (cs)
skos:notation	RIV/60076658:12310/06:00008791!RIV08-MSM-12310___
http://linked.open.../vavai/riv/strany	1475-1485
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Trantírek, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	501944
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/06:00008791
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NMR; structure; GA bulge; p65; TER; TERT (en)
http://linked.open.../riv/klicoveSlovo	TERT NMR structure p65 TER GA bulge
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DE4FF156475E]
http://linked.open...i/riv/nazevZdroje	RNA-A Publication of the RNA Society
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Trantírek, Lukáš Richards, Rebecca Feigon, Juli Wu, Haihong Collins, Kathleen O'Connor, Catherine
issn	1355-8382
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	12310
is http://linked.open...avai/riv/vysledek of	Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function

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