About: Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila

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About: Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Koaktivátor MBF1 zamezuje aktivitě redox dependenní AP-1 během oxidativního stresu v Drosophile (cs) Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by the redox state of critical cysteine residues within the basic regions of Jun and Fos. Mutation of these cysteines contributes to oncogenic potential of Jun and Fos. How cells maintain the redox-dependent AP-1 activity at favorable levels is not known. We show that the conserved coactivator MBF1 is a positive modulator of AP-1. Via a direct interaction with the basic region of Drosophila Jun (D-Jun), MBF1 prevents an oxidative modification (S-cystenyl cystenylation) of the critical cysteine and stimulates AP-1 binding to DNA. Cytoplasmic MBF1 translocates to the nucleus together with a transfected D-Jun protein, suggesting that MBF1 protects nascent D-Jun also in Drosophila cells. mbf1-null mutants live shorter than mbf1+ controls in the presence of hydrogen peroxide (H2O2). An AP-1-dependent epithelial cl Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by the redox state of critical cysteine residues within the basic regions of Jun and Fos. Mutation of these cysteines contributes to oncogenic potential of Jun and Fos. How cells maintain the redox-dependent AP-1 activity at favorable levels is not known. We show that the conserved coactivator MBF1 is a positive modulator of AP-1. Via a direct interaction with the basic region of Drosophila Jun (D-Jun), MBF1 prevents an oxidative modification (S-cystenyl cystenylation) of the critical cysteine and stimulates AP-1 binding to DNA. Cytoplasmic MBF1 translocates to the nucleus together with a transfected D-Jun protein, suggesting that MBF1 protects nascent D-Jun also in Drosophila cells. mbf1-null mutants live shorter than mbf1+ controls in the presence of hydrogen peroxide (H2O2). An AP-1-dependent epithelial cl (en)
Title	Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila (en) Koaktivátor MBF1 zamezuje aktivitě redox dependenní AP-1 během oxidativního stresu v Drosophile (cs)
skos:prefLabel	Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila (en) Koaktivátor MBF1 zamezuje aktivitě redox dependenní AP-1 během oxidativního stresu v Drosophile (cs)
skos:notation	RIV/60076658:12310/04:00008655!RIV08-MSM-12310___
http://linked.open.../vavai/riv/strany	3538-3547
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA204/04/1371), V, Z(AV0Z5007907)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jindra, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	557992
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/04:00008655
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	AP-1; coactivator; Drosophila; MBF-1; oxidative stress (en)
http://linked.open.../riv/klicoveSlovo	Drosophila oxidative stress coactivator AP-1 MBF-1
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A1964EEEC283]
http://linked.open...i/riv/nazevZdroje	EMBO Journal
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of AP-1 (Jun/Fos) activity by a coactivator MBF1 in Drosophila
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Jindra, Marek Uhlířová, M. Hirose, S. Hiromi, Y. Gažiová, I. Okabe, M.
http://linked.open...n/vavai/riv/zamer	The use of insects for quality assessment and possible management of the ecosystems in Central Europe
issn	0261-4189
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	12310

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