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| Description
| - Byla sledována citlivost tří typů imunodeficientích myší k infekci dvěma druhy mikrosporidií (Encephalitozoon cuniculi, Encephalitozoon intestinalis). Myši s těžkou kombinovanou imunodeficiencí (SCID) a myši s defektním genem pro syntézu interferonu gamma (IFN-gamma KO) podléhaly jak intraperitoneální (i.p.) tak perorální (p.o.) infekci oběma druhy mikrosporidií Puze i.p. infekce mikrosporidií E. cuniculi vedla k rozvoji letální infekce v přípdě myší s nefunkčním genem pro syntézu interleukinu 12 (IL-12 KO). IFN- gamma KO myši podléhali infekci dříve než myši SCID. Adoptivním přdnosem naivních splenocytů z IFN gamma KO myší do SCID myší se nepodařilo ochránit rekonstiované SCID myši před vznikem letální infekce. Ačkoli takto rekonstituované SCID myši přežívaly déle než nerekonstituované, což poukazuje na význam IFN gamma, který produkují NK buňky, ve vývoji protektivní imunity při těchto infekcích. IFN-gamma KO a IL-12 KO myši infikované E. intestinalis produkovaly srovnatelná množství specifických an (cs)
- Susceptibility of three strains of immunodeficient mice to two related microsporidian species Encephalitozoon cuniculi Levaditi, Nicolau et Schoen, 1923 and Encephalitozoon intestinalis (Cali, Kotler et Orenstein, 1993) was compared. While both, severe combined immunodeficient (SCID) and interferon-gamma knock-out (IFN-gamma KO) mice, succumbed to either intraperitoneal (i.p.) or peroral (p.o.) (natural) infection with both parasites, only i.p. infection with E. cuniculi killed interleukin-12 knock-out (IL-12 KO) mice. IFN-gamma KO mice died earlier than SCID mice. Adoptive transfer of naive splenocytes from IFN-gamma KO mice did not protect the SCID mice from a lethal infection with either of the Encephalitozoon species. However, reconstituted mice survived significantly longer (P<0.05), thus indicating the role of IFN-gamma produced by host NK cells in the development of mechanisms of anti-microsporidial protective immunity. Non-lethal outcome of the infection always correlated with the increase
- Susceptibility of three strains of immunodeficient mice to two related microsporidian species Encephalitozoon cuniculi Levaditi, Nicolau et Schoen, 1923 and Encephalitozoon intestinalis (Cali, Kotler et Orenstein, 1993) was compared. While both, severe combined immunodeficient (SCID) and interferon-gamma knock-out (IFN-gamma KO) mice, succumbed to either intraperitoneal (i.p.) or peroral (p.o.) (natural) infection with both parasites, only i.p. infection with E. cuniculi killed interleukin-12 knock-out (IL-12 KO) mice. IFN-gamma KO mice died earlier than SCID mice. Adoptive transfer of naive splenocytes from IFN-gamma KO mice did not protect the SCID mice from a lethal infection with either of the Encephalitozoon species. However, reconstituted mice survived significantly longer (P<0.05), thus indicating the role of IFN-gamma produced by host NK cells in the development of mechanisms of anti-microsporidial protective immunity. Non-lethal outcome of the infection always correlated with the increase (en)
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| Title
| - Susceptibility of IFN-gamma or IL-12 knock-out and SCID mice to infection with two microsporidian species, Encephalitozoon cuniculi and E-intestinalis
- Susceptibility of IFN-gamma or IL-12 knock-out and SCID mice to infection with two microsporidian species, Encephalitozoon cuniculi and E-intestinalis (en)
- Vnímavost myší s nefunkčním genem pro sytnézu IFN-gamma nebo IL-12 a SCID myší k mikrosporidiové infekci druhy Encephalitozoon cuniculi a E. intestinalis (cs)
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| skos:prefLabel
| - Susceptibility of IFN-gamma or IL-12 knock-out and SCID mice to infection with two microsporidian species, Encephalitozoon cuniculi and E-intestinalis
- Susceptibility of IFN-gamma or IL-12 knock-out and SCID mice to infection with two microsporidian species, Encephalitozoon cuniculi and E-intestinalis (en)
- Vnímavost myší s nefunkčním genem pro sytnézu IFN-gamma nebo IL-12 a SCID myší k mikrosporidiové infekci druhy Encephalitozoon cuniculi a E. intestinalis (cs)
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| skos:notation
| - RIV/60076658:12310/04:00005549!RIV/2005/MSM/123105/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60076658:12310/04:00005549
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - microsporidia;Encephalitozoon intestinalis;Encephalitozoon cuniculi;IFN-gamma knock-out;IL-12 knock-out;SCID mice (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kopecký, Jan
- Salát, Jiří
- Sak, B.
- Le, T.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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