About: Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor

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About: Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In addition to the fibrous (fibroins) and sticky (sericins) components, the silk contains several small peptides of unknown function. We demonstrate that two of the small peptides present in the silk of the waxmoth, Galleria mellonella, inhibit proteolytic enzymes, and are thus called silk proteinase inhibitors 1 and 2 (SPI 1, SPI 2). They are produced in the middle section of the silk-secreting glands prior to cocoon spinning and their production is controlled at the transcription level. The full length cDNA of pre-SPI 1 contains 443 nt and encodes a peptide of 76 amino acid residues, of which 20 make up a signal sequence. The mature SPI 1 (6056.7 Da, 56 residues) is a typical thermostable Kunitz-type proteinase inhibitor with Arg in P1 position. The cDNA of pre-SPI 2 consists of 260 nt and yields a putative secretory peptide of 58 amino acid residues. The functional SPI 2 (3993 Da, 36 residues), generated after the signal sequence removal, is a single-domain Kazal-type proteinase inhibitor with uniq In addition to the fibrous (fibroins) and sticky (sericins) components, the silk contains several small peptides of unknown function. We demonstrate that two of the small peptides present in the silk of the waxmoth, Galleria mellonella, inhibit proteolytic enzymes, and are thus called silk proteinase inhibitors 1 and 2 (SPI 1, SPI 2). They are produced in the middle section of the silk-secreting glands prior to cocoon spinning and their production is controlled at the transcription level. The full length cDNA of pre-SPI 1 contains 443 nt and encodes a peptide of 76 amino acid residues, of which 20 make up a signal sequence. The mature SPI 1 (6056.7 Da, 56 residues) is a typical thermostable Kunitz-type proteinase inhibitor with Arg in P1 position. The cDNA of pre-SPI 2 consists of 260 nt and yields a putative secretory peptide of 58 amino acid residues. The functional SPI 2 (3993 Da, 36 residues), generated after the signal sequence removal, is a single-domain Kazal-type proteinase inhibitor with uniq (en)
Title	Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor (en)
skos:prefLabel	Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor Insect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor (en)
skos:notation	RIV/60076658:12310/01:00003155!RIV/2002/GA0/123102/N
http://linked.open.../vavai/riv/strany	2064-2073
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA204/00/0019), P(ME 204)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Kodrík, Dalibor Sehnal, František Žurovec, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	683068
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/01:00003155
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antimicrobial defense; Galleria mellonella; Kazal domain; proteinase inhibitors; silk (en)
http://linked.open.../riv/klicoveSlovo	Galleria mellonella silk proteinase inhibitors Kazal domain antimicrobial defense
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[5A94359DE953]
http://linked.open...i/riv/nazevZdroje	European Journal of Biochemistry
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Revision of current understanding of the silk composition: identification and characterisation of 'small' silk proteins http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20204
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	268
http://linked.open...iv/tvurceVysledku	Kodrík, Dalibor Sehnal, František Žurovec, Michal Nirmala, X.
issn	0014-2956
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	12310

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