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Description
  • Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity.
  • Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity. (en)
Title
  • Alternative haematotoxicological testing
  • Alternative haematotoxicological testing (en)
skos:prefLabel
  • Alternative haematotoxicological testing
  • Alternative haematotoxicological testing (en)
skos:notation
  • RIV/60076658:12110/10:00012115!RIV11-MSM-12110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 246032
http://linked.open...ai/riv/idVysledku
  • RIV/60076658:12110/10:00012115
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • IN-VITRO; COMPUTATIONAL TOXICOLOGY; ANTIFOULING COMPOUNDS MICRONUCLEUS TEST; ANTICANCER DRUGS; HEMOCYTES; TOXICITY; ASSAY; RESPONSES; IMMUNOTOXICITY (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [ACA598B2B937]
http://linked.open...i/riv/nazevZdroje
  • Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Berger, Josef
http://linked.open...ain/vavai/riv/wos
  • 000274244600003
issn
  • 1214-021X
number of pages
http://localhost/t...ganizacniJednotka
  • 12110
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