About: Genetic Diversity And Polymorphisms of Czech National Marrow Donors Registry for Use in Recruitment And Typing Strategies     Goto   Sponge   NotDistinct   Permalink

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Description
  • Analysis of the genetic diversity was focused on A, B, C, DRB1, DQB1 loci, B-C and DRB1-DQB1 associations, haplotypes and fenotypes occurence and contribution of each cooperating donor center (allele groups). Results are needed to streamline recruiting activities and for search methods innovation, especially because of some donors' insufficient typing level. According the analysis results the registry shows the standard distribution of the Caucasian population, e.g. the most frequent B-C association are B*07-C*07 and B*08-C*07 and the most frequent DRB1-DQB1 associations are DRB1*15-DQB1*06 and DRB1*03-DQB1*02. The most interested for possible future use are results of promiscuous B allelic groups (like B*51, B*27 or B*18). The association is quite often strongly dependent on the haplotype. Between donor centers there are no big differences for the most frequent phenotypes, for haplotypes slightly so.
  • Analysis of the genetic diversity was focused on A, B, C, DRB1, DQB1 loci, B-C and DRB1-DQB1 associations, haplotypes and fenotypes occurence and contribution of each cooperating donor center (allele groups). Results are needed to streamline recruiting activities and for search methods innovation, especially because of some donors' insufficient typing level. According the analysis results the registry shows the standard distribution of the Caucasian population, e.g. the most frequent B-C association are B*07-C*07 and B*08-C*07 and the most frequent DRB1-DQB1 associations are DRB1*15-DQB1*06 and DRB1*03-DQB1*02. The most interested for possible future use are results of promiscuous B allelic groups (like B*51, B*27 or B*18). The association is quite often strongly dependent on the haplotype. Between donor centers there are no big differences for the most frequent phenotypes, for haplotypes slightly so. (en)
Title
  • Genetic Diversity And Polymorphisms of Czech National Marrow Donors Registry for Use in Recruitment And Typing Strategies
  • Genetic Diversity And Polymorphisms of Czech National Marrow Donors Registry for Use in Recruitment And Typing Strategies (en)
skos:prefLabel
  • Genetic Diversity And Polymorphisms of Czech National Marrow Donors Registry for Use in Recruitment And Typing Strategies
  • Genetic Diversity And Polymorphisms of Czech National Marrow Donors Registry for Use in Recruitment And Typing Strategies (en)
skos:notation
  • RIV/49777513:23520/12:43918237!RIV13-TA0-23520___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • P(TA01010342)
http://linked.open...vai/riv/dodaniDat
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  • 137901
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  • RIV/49777513:23520/12:43918237
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  • typing strategies; donor recruitment; gene and phenotypes frequency; gene associations; genetic diversity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [14382520D699]
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Georgiev, Daniel
  • Houdová, Lucie
http://localhost/t...ganizacniJednotka
  • 23520
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