About: The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis

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About: The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/jssc.201201144/abstract
Description	This work documents the influence of the position of single carboxymethyl group on the β-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native β-cyclodextrin, and commercially available carboxymethyl-β-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-mass chiral compounds were enantioseparated by CE. The results indicate that different substituent location on β-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2I-O-regioisomer was better than with native β-cyclodextrin. Comparable results to native β-cyclodextrin were obtained for 6I-O- regioisomer and the enantioselectivity of 3I-O-regioisomer was even worse than with native β-cyclodextrin. Commercially available derivative of CD provides better resolutions than the monosubstituted carboxymethyl CD derivatives for most of the investigated analytes. This work documents the influence of the position of single carboxymethyl group on the β-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native β-cyclodextrin, and commercially available carboxymethyl-β-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-mass chiral compounds were enantioseparated by CE. The results indicate that different substituent location on β-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2I-O-regioisomer was better than with native β-cyclodextrin. Comparable results to native β-cyclodextrin were obtained for 6I-O- regioisomer and the enantioselectivity of 3I-O-regioisomer was even worse than with native β-cyclodextrin. Commercially available derivative of CD provides better resolutions than the monosubstituted carboxymethyl CD derivatives for most of the investigated analytes. (en)
Title	The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis (en)
skos:prefLabel	The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis (en)
skos:notation	RIV/46747885:24620/13:#0000110!RIV14-MSM-24620___
http://linked.open...avai/predkladatel	Ústav pro nanomateriály, pokročilé technologie a inovace
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0005/01/01), P(EE2.3.30.0024)
http://linked.open...iv/cisloPeriodika	36
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Řezanka, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Technická univerzita v Liberci / Ústav pro nanomateriály, pokročilé technologie a inovace
http://linked.open...dnocenehoVysledku	108692
http://linked.open...ai/riv/idVysledku	RIV/46747885:24620/13:#0000110
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CE, Chiral separation, Enantioselectivity, Monosubstituted carboxymethyl-β-cyclodextrin, Regioisomer (en)
http://linked.open.../riv/klicoveSlovo	Enantioselectivity Monosubstituted carboxymethyl-β-cyclodextrin Regioisomer CE Chiral separation
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[D04F84CD52A5]
http://linked.open...i/riv/nazevZdroje	Journal of Separation Science
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for nanomaterials, advanced technologies and innovation Development of research teams of R & D projects at the Technical University of Liberec
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Řezanka, Michal
issn	1615-9306
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jssc.201201144
http://localhost/t...ganizacniJednotka	24620

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