About: Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tissue engineering applications widely use nanofibrous scaffolds due to their similarity to native extracellular matrix. Polycaprolactone (PCL) nanofibers have excellent properties for cell attachment. The platelet growth factors promote cell proliferation. Platelet rich plasma is clinically used in chronic wound treatment and in orthopedic applications (nonunionized fractures, total joint replacement). The aim of presented study is the development of nanofibrous layers functionalized by thrombocytes. The effect of platelet growth factors for fibroblast proliferation was tested. PCL nanofibers were immersed for 2 hours in thrombocyte rich solution (TRS) to enable thrombocyte adhesion. These scaffolds were thereafter seeded with fibroblasts. PCL nanofibrous layers without immobilized thrombocytes were used as a control. The presence of thrombocytes after 2 hour incubation was confirmed by scanning electrone microscopy (SEM). Proliferation of seeded fibroblasts on functionalized scaffolds were tested by MTT assay. The nanofibrous scaffold with attached thrombocytes can be used as an efficient drug delivery system for tissue engineering applications. Tissue engineering applications widely use nanofibrous scaffolds due to their similarity to native extracellular matrix. Polycaprolactone (PCL) nanofibers have excellent properties for cell attachment. The platelet growth factors promote cell proliferation. Platelet rich plasma is clinically used in chronic wound treatment and in orthopedic applications (nonunionized fractures, total joint replacement). The aim of presented study is the development of nanofibrous layers functionalized by thrombocytes. The effect of platelet growth factors for fibroblast proliferation was tested. PCL nanofibers were immersed for 2 hours in thrombocyte rich solution (TRS) to enable thrombocyte adhesion. These scaffolds were thereafter seeded with fibroblasts. PCL nanofibrous layers without immobilized thrombocytes were used as a control. The presence of thrombocytes after 2 hour incubation was confirmed by scanning electrone microscopy (SEM). Proliferation of seeded fibroblasts on functionalized scaffolds were tested by MTT assay. The nanofibrous scaffold with attached thrombocytes can be used as an efficient drug delivery system for tissue engineering applications. (en)
Title	Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution (en)
skos:prefLabel	Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution (en)
skos:notation	RIV/46747885:24410/13:#0001756!RIV14-GA0-24410___
http://linked.open...avai/predkladatel	Fakulta textilní
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP208/12/0105), S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Mikeš, Petr Jenčová, Věra Cudlínová, Marcela Horáková, Jana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Technická univerzita v Liberci / Fakulta textilní
http://linked.open...dnocenehoVysledku	97058
http://linked.open...ai/riv/idVysledku	RIV/46747885:24410/13:#0001756
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Electrospinning, Nanofibers, Polycaprolactone, Thrombocyte Rich Solution (en)
http://linked.open.../riv/klicoveSlovo	Electrospinning Nanofibers Polycaprolactone Thrombocyte Rich Solution
http://linked.open...ontrolniKodProRIV	[F5DF9559437A]
http://linked.open...in/vavai/riv/obor	JJ
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	POLYMER SOLUTIONS IN AN EXTERNAL FIELD: MOLECULAR UNDERSTANDING OF ELECTROSPINNING
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Horáková, Jana Mikeš, Petr Cudlínová, Marcela Ročková, Kateřina Jenčová, Věra Procházková, R.
http://localhost/t...ganizacniJednotka	24410

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